concept

ALZHEIMER'S

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALZHEIMER'S: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1571Connections

17Hypotheses

30Analyses

50Outgoing

50Incoming

Summary

ALZHEIMER'S is a concept in neurodegeneration research. Key relationships include: co discussed, causes, associated with. Associated with ALS, ALZHEIMER, ALZHEIMER'S DISEASE. Connected to 332 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ALZHEIMER'S
Key Genes/Proteins	APOE, APOE4
Related Diseases	DEMENTIA, NEURODEGENERATION, ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, TUMOR
Linked Hypotheses	17 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Corticobasal Syndrome (CBS)

disease · 11374 words

→

Pathway Diagram

graph TD
    ALZHEIMER_S["ALZHEIMER'S"]
    ALZHEIMER_S ---|"co-discussed"| CD2AP["CD2AP"]
    ALZHEIMER_S ---|"co-discussed"| APOE["APOE"]
    ALZHEIMER_S ---|"co-discussed"| DEPRESSION["DEPRESSION"]
    ALZHEIMER_S ---|"co-discussed"| EPILEPSY["EPILEPSY"]
    ALZHEIMER_S ---|"co-discussed"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    ALZHEIMER_S ---|"co-discussed"| MICROGLIA["MICROGLIA"]
    ALZHEIMER["ALZHEIMER"] ---|"co-discussed"| ALZHEIMER_S
    ALS["ALS"] ---|"co-discussed"| ALZHEIMER_S
    ABETA["ABETA"] ---|"co-discussed"| ALZHEIMER_S

Outgoing (706)

Target	Relation	Type	Str
NEURONS	causes_injury_to	cell_type	0.80
air pollution	implicated_in	environmental_factor	0.80
DEMENTIA	promotes	disease	0.65
NEURODEGENERATION	activates	disease	0.65
NEURODEGENERATION	treats	disease	0.65
NEURON	treats	cell_type	0.65
DEMENTIA	protects_against	disease	0.65
DEMENTIA	regulates	disease	0.65
ALZHEIMER'S DISEASE	reduces	disease	0.65
DEMENTIA	reduces	disease	0.65
MULTIPLE SCLEROSIS	impairs	disease	0.65
ALZHEIMER'S DISEASE	increases	disease	0.65
APOE	increases	gene	0.65
APOE4	increases	gene	0.65
TUMOR	associated_with	disease	0.65
DEMENTIA	biomarker_for	disease	0.65
GFAP	biomarker_for	gene	0.65
STING	biomarker_for	gene	0.65
NLRP3	regulates	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	activates	disease	0.65
DEMENTIA	activates	disease	0.65
FRONTOTEMPORAL	activates	disease	0.65
FTD	activates	disease	0.65
PARKIN	activates	gene	0.65
PARKINSON	activates	disease	0.65
PARKINSON'S	activates	disease	0.65
PARKINSON'S DISEASE	activates	disease	0.65
HUNTINGTON	activates	disease	0.65
HUNTINGTON'S	activates	disease	0.65
ALZHEIMER'S DISEASE	sensitizes_to	disease	0.65
NEURON	accumulates_in	cell_type	0.65
NEURONS	accumulates_in	cell_type	0.65
CGAS	activates	gene	0.65
IL-6	activates	gene	0.65
STAT3	activates	gene	0.65
DEPRESSION	treats	disease	0.65
T CELL	causes	cell_type	0.65
TREM2	biomarker_for	gene	0.65
STING	promotes	gene	0.65
NEURODEGENERATION	inhibits	disease	0.65
ALZHEIMER'S DISEASE	accumulates_in	disease	0.65
NEURODEGENERATION	accumulates_in	disease	0.65
PARKINSON'S DISEASE	accumulates_in	disease	0.65
MACROPHAGE	associated_with	cell_type	0.65
MACROPHAGES	associated_with	cell_type	0.65
GLIOMA	treats	disease	0.65
MENINGITIS	treats	disease	0.65
NEURONS	contributes_to	cell_type	0.65
STING	increases	gene	0.65
CD2AP	associated_with	gene	0.65

Incoming (865)

Source	Relation	Type	Str
ALZHEIMER	promotes	disease	0.65
ALZHEIMER	reduces	disease	0.65
ALZHEIMER	increases	disease	0.65
ALS	activates	disease	0.65
ALZHEIMER	sensitizes_to	disease	0.65
ALZHEIMER	inhibits	disease	0.65
ALZHEIMER	processes	disease	0.65
ALZHEIMER	accumulates_in	disease	0.65
ALZHEIMER	treats	disease	0.60
ALZHEIMER	contributes_to	disease	0.60
ALZHEIMER	protects_against	disease	0.60
ALZHEIMER	targets	disease	0.60
ALZHEIMER	interacts_with	disease	0.60
ALZHEIMER	associated_with	disease	0.60
ALZHEIMER	expressed_in	disease	0.60
ALZHEIMER	causes	disease	0.60
ALZHEIMER	impairs	disease	0.60
ACHE	treats	gene	0.60
ALZHEIMER	biomarker_for	disease	0.60
ALZHEIMER	exacerbates	disease	0.60
ACHE	causes	gene	0.60
ALZHEIMER	activates	disease	0.60
ALZHEIMER	mediates	disease	0.60
ALS	causes	disease	0.60
ALZHEIMER	regulates	disease	0.60
AKT	contributes_to	gene	0.60
ALS	associated_with	disease	0.60
ALS	contributes_to	disease	0.60
ABCA1	contributes_to	gene	0.60
ACHE	targets	gene	0.60
ACHE	contributes_to	gene	0.60
ALS	expressed_in	disease	0.60
ALZHEIMER	co_discussed	entity	0.50
ALS	co_discussed	entity	0.50
ABETA	co_discussed	entity	0.50
Alzheimer'S Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
Alzheimer'S Disease	inhibits	disease	0.50
AMYLOID	inhibits	gene	0.50
disease	inhibits	disease	0.50
CD2AP	interacts_with	protein	0.50
disease	interacts_with	disease	0.50
Alzheimer'S Disease	protects_against	disease	0.50
disease	protects_against	disease	0.50
APOE	associated_with	gene	0.50
REELIN	associated_with	protein	0.50
AUTISM	interacts_with	disease	0.50
DEPRESSION	interacts_with	disease	0.50
EPILEPSY	interacts_with	gene	0.50
lissencephaly	interacts_with	disease	0.50

Targeting Hypotheses (17)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound to restore hippo	0.709	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with 40Hz gamma	0.689	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop transcranial focused ultrasound to restore hippo	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.566	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.557	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.554	Alzheimer's disease	Circuit-level neural dynamics in neurode
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.512	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.508	Alzheimer's disease	Circuit-level neural dynamics in neurode
Microglial TREM2 downregulation impairs damage-associated re	0.507	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to R	0.498	neuroinflammation	Why do TAM receptors protect against neu
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.497	neurodegeneration	Are interneuron oscillation deficits com
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Epigenetic Memory Reprogramming for Alzheimer's Disease	0.467	neurodegeneration	CRISPR-based therapeutic approaches for

Mentioning Analyses (30)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987]	Vadalà A, Benelli C, Suraci F, Carta B,	Arch Orthop Trauma Surg	2026
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068]	Yang S, Wang X, Yan Y, Zhang J, Wei Y et	J Affect Disord	2026
Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly. [PMID:39973610]	Gelot AB, Draia-Nicolau TO, Mathieu R, S	Epilepsia	2025
Brain connectivity and transcriptional changes induced by rTMS in first-episode [PMID:40274783]	Guan M, Xie Y, Wang Z, Miao Y, Li X et a	Transl Psychiatry	2025
Single-cell RNA sequencing of adult primate neocortex reveals the regulatory dyn [PMID:40385068]	Zhang C, Xie Z, Wang N	Am J Transl Res	2025
Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475]	Bershteyn M, Zhou H, Fuentealba L, Chen	Neuron	2025
Enhancer AAV toolbox for accessing and perturbing striatal cell types and circui [PMID:40403704]	Hunker AC, Wirthlin ME, Gill G, Johansen	Neuron	2025
Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284]	Walsh RM, Crabtree GW, Kalpana K, Jubier	Neuron	2025
Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404]	Qi C, Sima W, Mao H, Hu E, Ge J et al.	Nat Commun	2025
Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329]	Morabito A, Zerlaut Y, Dhanasobhon D, Be	Neuron	2025
Targeting SARM1 improves autophagic stress-induced axonal neuropathy. [PMID:37561040]	Kim HR, Lee HJ, Jeon Y, Jang SY, Shin YK	Autophagy	2024
Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379]	Gabitto MI, Travaglini KJ, Rachleff VM,	Nat Neurosci	2024
Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656]	Wang W, Lu J, Pan N, Zhang H, Dai J et a	Front Immunol	2024
Cortical somatostatin long-range projection neurons and interneurons exhibit div [PMID:38086373]	Fisher J, Verhagen M, Long Z, Moissidis	Neuron	2024
Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behavio [PMID:38155473]	Zhang Q, Xue Y, Wei K, Wang H, Ma Y et a	Adv Sci (Weinh)	2024
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing Res Rev	2024
Somatostatin interneurons control the timing of developmental desynchronization [PMID:38599213]	Mòdol L, Moissidis M, Selten M, Oozeer F	Neuron	2024
De novo gene synthesis by an antiviral reverse transcriptase. [PMID:39116258]	Tang S, Conte V, Zhang DJ, Žedaveinytė R	Science	2024
Signature morphoelectric properties of diverse GABAergic interneurons in the hum [PMID:37824669]	Lee BR, Dalley R, Miller JA, Chartrand T	Science	2023
Novel App knock-in mouse model shows key features of amyloid pathology and revea [PMID:35690868]	Xia D, Lianoglou S, Sandmann T, Calvert	Mol Neurodegener	2022

ALZHEIMER'S

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

Pathway Diagram

Outgoing (706)

Incoming (865)

Targeting Hypotheses (17)

Mentioning Analyses (30)

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What are the physiological functions of BACE1 beyond APP processing that could c

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

What signals trigger microglia to specifically recognize and phagocytose LC axon

Why have anti-Aβ clinical trials failed despite the established role of Aβ in AD

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Are autophagy-lysosome defects primary drivers or downstream consequences in spo

What mechanisms underlie TDP-43's contribution to cognitive impairment severity

What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease versu

How does APOE4 mechanistically increase TDP-43 pathology frequency in Alzheimer'

Does SPP1-mediated synaptic engulfment represent beneficial clearance or patholo

How do perivascular cells specifically recognize and respond to amyloid-β to upr

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Neuroinflammation and microglial priming in early AD

SEA-AD Single-Cell Analysis: Cell-Type Vulnerability in Alzheimer's Disease

Neuroinflammation and microglial priming in early Alzheimer's Disease

Senescent cell clearance as neurodegeneration therapy

SEA-AD Single-Cell Analysis: Cell-Type Vulnerability in Alzheimer's Disease

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

APOE4 targeting in neurodegeneration

Entorhinal cortex layer II vulnerability in Alzheimer's disease

Cell type vulnerability debate in Alzheimer's disease (SEA-AD v4)

Synaptic pruning by microglia in neurodegeneration

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

Related Papers (20)