Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MIEF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MIEF1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Als, Cancer, Ms. Connected to 16 entities in the SciDEX knowledge graph.
| Gene Symbol | MIEF1 |
| Chromosome | 17q11.2 |
| Function | MIEF1 localizes to the mitochondrial outer membrane where it recruits Drp1 from the cytosol to the mitochondrial surface, initiating the fission process. |
| Primary Expression | Ubiquitous, highest in brain, heart, and muscle |
| Amino Acids | 463 aa |
| Pathways | Complement |
| UniProt ID | Q9H0X6 |
| NCBI Gene ID | 54443 |
| Ensembl ID | ENSG00000135269 |
| GeneCards | MIEF1 |
| Human Protein Atlas | MIEF1 |
| Official Symbol | MIEF1 |
| Official Full Name | Mitochondrial Elongation Factor 1 |
| Also Known As | MiD49, SMCR7L, DNDP1, MID51, MIEF2 (paralog) |
| Protein Length | 463 amino acids |
| Associated Diseases | neurodegeneration |
| Interactions | NRF2, DRP1, CANCER, OXIDATIVE STRESS |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
MIEF1["<b>MIEF1</b>"]
Cancer{"Cancer"}
MIEF1 -->|"activates"| Cancer
Als{"Als"}
MIEF1 -->|"regulates"| Als
Ms{"Ms"}
MIEF1 -->|"regulates"| Ms
NRF2["NRF2"]
MIEF1 -->|"activates"| NRF2
DRP1["DRP1"]
MIEF1 -->|"activates"| DRP1
Oxidative_Stress(["Oxidative Stress"])
MIEF1 -->|"activates"| Oxidative_Stress
TAZ["TAZ"]
MIEF1 -->|"regulates"| TAZ
Complement(["Complement"])
MIEF1 -->|"regulates"| Complement
CANCER["CANCER"]
MIEF1 -->|"activates"| CANCER
OXIDATIVE_STRESS["OXIDATIVE STRESS"]
MIEF1 -->|"activates"| OXIDATIVE_STRESS
neurodegeneration["neurodegeneration"]
MIEF1 -->|"implicated in"| neurodegeneration
SREBP1["SREBP1"]
SREBP1 -->|"regulates"| MIEF1
DRP1 -->|"regulates"| MIEF1
YAP["YAP"]
YAP -->|"regulates"| MIEF1
NRF2 -->|"regulates"| MIEF1
DRP1 -->|"activates"| MIEF1
style MIEF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| NRF2 | activates | gene | 0.60 |
| DRP1 | activates | gene | 0.60 |
| TAZ | regulates | gene | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| Complement | regulates | pathway | 0.60 |
| CANCER | activates | gene | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||