gene

MIEF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MIEF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections
0Hypotheses
0Analyses
10Outgoing
5Incoming

Summary

MIEF1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Als, Cancer, Ms. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolMIEF1
Chromosome17q11.2
FunctionMIEF1 localizes to the mitochondrial outer membrane where it recruits Drp1 from the cytosol to the mitochondrial surface, initiating the fission process.
Primary ExpressionUbiquitous, highest in brain, heart, and muscle
Amino Acids463 aa
PathwaysComplement
UniProt IDQ9H0X6
NCBI Gene ID54443
Ensembl IDENSG00000135269
GeneCardsMIEF1
Human Protein AtlasMIEF1
Official SymbolMIEF1
Official Full NameMitochondrial Elongation Factor 1
Also Known AsMiD49, SMCR7L, DNDP1, MID51, MIEF2 (paralog)
Protein Length463 amino acids
Associated Diseasesneurodegeneration
InteractionsNRF2, DRP1, CANCER, OXIDATIVE STRESS
KG Connections15 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: MIEF1 — AlphaFold Q9H0X6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

mief1

gene · 1927 words

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

mechanism · 3314 words

mid49

gene · 2058 words

MIEF2 — Mitochondrial Elongation Factor 2 (MiD50)

gene · 1575 words

MID51

gene · 1045 words

Genes

index · 271 words

Pathway Diagram

graph TD
    MIEF1["<b>MIEF1</b>"]
    Cancer{"Cancer"}
    MIEF1 -->|"activates"| Cancer
    Als{"Als"}
    MIEF1 -->|"regulates"| Als
    Ms{"Ms"}
    MIEF1 -->|"regulates"| Ms
    NRF2["NRF2"]
    MIEF1 -->|"activates"| NRF2
    DRP1["DRP1"]
    MIEF1 -->|"activates"| DRP1
    Oxidative_Stress(["Oxidative Stress"])
    MIEF1 -->|"activates"| Oxidative_Stress
    TAZ["TAZ"]
    MIEF1 -->|"regulates"| TAZ
    Complement(["Complement"])
    MIEF1 -->|"regulates"| Complement
    CANCER["CANCER"]
    MIEF1 -->|"activates"| CANCER
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    MIEF1 -->|"activates"| OXIDATIVE_STRESS
    neurodegeneration["neurodegeneration"]
    MIEF1 -->|"implicated in"| neurodegeneration
    SREBP1["SREBP1"]
    SREBP1 -->|"regulates"| MIEF1
    DRP1 -->|"regulates"| MIEF1
    YAP["YAP"]
    YAP -->|"regulates"| MIEF1
    NRF2 -->|"regulates"| MIEF1
    DRP1 -->|"activates"| MIEF1
    style MIEF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

TargetRelationTypeStr
Canceractivatesdisease0.65
Alsregulatesdisease0.65
Msregulatesdisease0.65
NRF2activatesgene0.60
DRP1activatesgene0.60

Incoming (5)

SourceRelationTypeStr
DRP1regulatesgene0.60
NRF2regulatesgene0.60
DRP1activatesgene0.60
SREBP1regulatesgene0.60
YAPregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found