gene

TAZ

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAZ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

222Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

TAZ is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with Aging, Als, Breast Cancer. Connected to 146 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TAZ
Full Name	WW Domain Containing Transcription Regulator 1
Chromosome	3q24
Function	is a key transcriptional co-activator in the Hippo signaling pathway.
Amino Acids	400 aa
Pathways	Blood-Brain Barrier, Complement, Epigenetic, Hedgehog, Hippo Pathway
UniProt ID	[Q9GZV0](https://www.uniprot.org/uniprot/Q9GZV0)
Ensembl ID	ENSG00000118445
GeneCards	TAZ
Human Protein Atlas	TAZ
isoform 1	Full-length protein (400 amino acids)
Shorter isoforms	Generated through alternative splicing, these may have distinct functional properties
Associated Diseases	Als, Cancer, Carcinoma, Multiple Sclerosis, Neurodegeneration, Pancreatic Cancer
Interactions	LATS2, SPR, APC, RB1, RB1CC1, EGF
KG Connections	222 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TAZ["TAZ"]
    TAZ -->|"regulates"| Cardiovascular["Cardiovascular"]
    TAZ -->|"regulates"| Cancer["Cancer"]
    TAZ -->|"regulates"| Ms["Ms"]
    TAZ -->|"activates"| Fibrosis["Fibrosis"]
    TAZ -->|"regulates"| Ischemia["Ischemia"]
    TAZ -->|"activates"| Stroke["Stroke"]
    TAZ -->|"regulates"| Als["Als"]
    TAZ -->|"activates"| Tumor["Tumor"]
    Hippo_pathway["Hippo pathway"] -->|"regulates"| TAZ
    CDH1["CDH1"] -->|"regulates"| TAZ
    LATS1["LATS1"] -->|"regulates"| TAZ
    YAP["YAP"] -->|"regulates"| TAZ
    SREBP1["SREBP1"] -->|"regulates"| TAZ
    DRP1["DRP1"] -->|"regulates"| TAZ
    NRF2["NRF2"] -->|"regulates"| TAZ
    MIEF1["MIEF1"] -->|"regulates"| TAZ
    DDB1["DDB1"] -->|"regulates"| TAZ
    PIEZO1["PIEZO1"] -.protects against.-> TAZ

Outgoing (153)

Target	Relation	Type	Str
FOXO1	activates	gene	0.95
Neuronal Apoptosis	suppresses	process	0.90
Ischemic Stroke	protects_against	disease	0.90
Antioxidant Defense	regulates	pathway	0.85
Oxidative Damage	modulates	process	0.80
YAP	activates	gene	0.80
Cancer	regulates	disease	0.75
Als	regulates	disease	0.75
Tumor	activates	disease	0.75
Cancer	activates	disease	0.75
Breast Cancer	activates	disease	0.75
LATS1	regulates	gene	0.70
Yap/Taz	inhibits	pathway	0.70
Yap/Taz	activates	pathway	0.70
YAP	inhibits	gene	0.70
CANCER	activates	gene	0.70
YAP	associated_with	gene	0.70
HIPPO	regulates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
Ms	regulates	disease	0.65
Ms	activates	disease	0.65
Fibrosis	activates	disease	0.65
Ischemia	regulates	disease	0.65
Stroke	activates	disease	0.65
Als	activates	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Senescence	inhibits	disease	0.65
Aging	regulates	disease	0.65
Inflammation	activates	disease	0.65
Carcinoma	inhibits	disease	0.65
Als	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Als	inhibits	disease	0.65
Pancreatic Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Aging	activates	disease	0.65
Dementia	activates	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
Pulmonary Fibrosis	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Fibrosis	regulates	disease	0.65
DDB1	regulates	gene	0.60
PIEZO1	protects_against	gene	0.60
MFSD2A	regulates	gene	0.60

Incoming (69)

Source	Relation	Type	Str
Hippo pathway	regulates	pathway	0.90
USP1	associated_with	gene	0.90
CDH1	regulates	gene	0.70
LATS1	regulates	gene	0.60
DRP1	regulates	gene	0.60
NRF2	regulates	gene	0.60
MIEF1	regulates	gene	0.60
DDB1	regulates	gene	0.60
PIEZO1	protects_against	gene	0.60
SOX2	regulates	gene	0.60
MTOR	regulates	gene	0.60
LATS1	activates	gene	0.60
PINK1	activates	gene	0.60
PARKIN	activates	gene	0.60
GAL	regulates	gene	0.60
SRC	activates	gene	0.60
SRC	inhibits	gene	0.60
BMAL1	regulates	gene	0.60
CLOCK	regulates	gene	0.60
MST1	activates	gene	0.60
HDAC6	activates	gene	0.60
DRD1	inhibits	gene	0.60
PIEZO1	expressed_in	entity	0.60
FUS	interacts_with	gene	0.60
FUS	regulates	gene	0.60
FUS	inhibits	gene	0.60
FUS	activates	gene	0.60
SOD2	activates	gene	0.60
AXIN1	implicated_in	gene	0.60
CTNNB1	implicated_in	gene	0.60
AXIN1	regulates	gene	0.60
AXIN1	targets	gene	0.60
STING	activates	gene	0.60
BDNF	activates	gene	0.60
YAP	regulates	gene	0.60
SREBP1	regulates	gene	0.60
POSTN	activates	gene	0.60
HIPPO	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
AGING	regulates	gene	0.60
HIPPO	regulates	gene	0.60
HIPPO	associated_with	gene	0.60
KRAS	activates	gene	0.60
ERK	inhibits	gene	0.60
CANCER	regulates	gene	0.60
YAP	protects_against	gene	0.60
ATG	activates	gene	0.60
AXON	implicated_in	gene	0.60
INFLAMMATION	activates	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ASO-Mediated Exon Skipping to Restore FUS-TAZ Chaperone Axis	0.606	neurodegeneration	How does FUS loss-of-function in TAZ reg

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.606

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TAZ

Understanding Entity Pages

Summary

Wiki Pages (21)

TAZ (WWTR1)

Corticobasal Syndrome (CBS)

Novel Therapy Index

TEAD1 — TEA Domain Transcription Factor 1

DVL3 — Dishevelled Segment Polarity Protein 3

RAN Gene

YAP/TAZ Signaling Pathway in Neurodegeneration

Meningeal Fibroblasts

YAP/TAZ (Hippo) Signaling in Neurodegeneration

SLIT2 — Slit Guidance Ligand 2

SYNE2 Gene

MITF Gene — Microphthalmia-Associated Transcription Factor

CCM2 Protein

mief1

Hippo Signaling Pathway in Neurodegeneration

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

WWTR1 (TAZ) — WW Domain Containing Transcription Regulator 1, Hippo Effector

YWHAB Gene

DDB1 — DNA Damage Binding Protein 1

ANKRD1 — Ankyrin Repeat Domain 1