Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MMP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Glycocalyx | degrades | biomarker | 0.95 |
| Hypertrophic Scar | drives | disease | 0.85 |
| ischemic stroke | implicated_in | disease | 0.80 |
| Blood-Brain Barrier Dysfunction | mediates | phenotype | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TNF | activates | protein | 0.90 |
| IL1B | activates | protein | 0.90 |
| exosomes | inhibits | protein | 0.85 |
| 5-fluorouracil | suppresses | drug | 0.80 |
| ASH1L | inhibits | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 14 hypotheses Top: 0.806
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Resveratrol protection against renal I/R injury in diabetic rats | validation | diabetic nephropathy | 0.900 | 0.00 | streptozotocin-induced diabeti | proposed | N/A |
| Resveratrol effects on HK-2 cells under hypoxia/reoxygenation | exploratory | diabetic nephropathy | 0.850 | 0.00 | HK-2 cells cultured in high gl | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] | Chua JP, De Calbiac H, Kabashi E, Barmad | Autophagy | 2022 | 2 |
| Loss of Nuclear TDP-43 Impairs Lipid Metabolism in Microglia-Like Cells. [PMID:41000837] | Unknown | bioRxiv | 2025 | 0 |
| Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology a [PMID:36201573] | Unknown | Science | 2022 | 0 |
| Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopat [PMID:34412701] | Unknown | Acta Neuropathol Commun | 2021 | 0 |
| Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP- [PMID:30458231] | Unknown | Neurobiology of disease | 2019 | 0 |
| TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and i [PMID:30146158] | Xu D, Jin T, Zhu H, Chen H, Ofengeim D, | Cell | 2018 | 0 |
| TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synaps [PMID:28669544] | Unknown | Neuron | 2017 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.76 · 2026-04-23
closed · Rounds: 7 · Score: 0.87 · 2026-04-16
Hypotheses and analyses mentioning MMP in their description or question text
Score: 0.499 · als · 2026-04-27
This hypothesis proposes that TBK1 loss-of-function mutations initiate a pathological cascade where microglia become loc
Score: 0.425 · unknown disease · 2026-04-26
Trazodone's 5-HT2A antagonism reduces matrix metalloproteinase-9 (MMP-9) expression in cerebral endothelial cells, prese
Score: 0.376 · als · 2026-04-26
TBK1 deficiency in microglia creates a pathological cascade that directly generates ALS-driving TDP-43 pathology through
Score: 0.361 · als · 2026-04-26
This hypothesis proposes that MMP-9 secreted by senescent microglia in the SASP drives ALS pathology through disruption
Score: 0.000 · unknown disease · 2026-04-28
Triple-target therapy combining PAD4 inhibitors to block neutrophil extracellular trap formation, selective MMP inhibito