gene 582 words KG: MMP3 2026-03-24
kind:genesection:genesstate:published
Contents

MMP3 Gene

🧬 Gene Info
Gene SymbolMMP3
Chromosome11q22.3.
FunctionMMP3 encodes matrix metalloproteinase 3 (MMP-3), also known as stromelysin-1, a member of the zinc-dependent metalloproteinase family.
PathwaysFerroptosis, Synaptic Plasticity, Long-Term Potentiation, Oxidative Stress, Apoptosis
Ensembl IDENSG00000149968
GeneCardsMMP3
Human Protein AtlasMMP3
Associated DiseasesAtherosclerosis, Inflammation, Stroke
Known Drugs/Compoundsicariin
InteractionsGPX4, SOX9, SLC7A11, MMP1, FER, TNFAIP6
KG Connections139 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (7)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: activates
ICAM1 - Intercellular Adhesion Molecule 1
gene · KG edge: associated_with
HMOX1 — Heme Oxygenase 1
gene · KG edge: associated_with
HMGCR — 3-Hydroxy-3-Methylglutaryl-CoA Reductase
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

MMP3 activates GPX4
MMP3 activates SOX9
MMP3 activates SLC7A11
MMP3 activates MMP1
MMP3 activates FER
MMP3 associated_with STAT3
MMP3 inhibits SLC7A11
MMP3 inhibits Arthritis
MMP3 associated_with APOE
MMP3 associated_with SPP1