Contents

MMP14 (Matrix Metalloproteinase 14)

🧬 Gene Info

Gene Symbol	MMP14
Aliases	Matrix Metalloproteinase 14
Function	MMP14 serves multiple physiological functions
Molecular Weight	63 kDa
Pathways	Mapk, Apoptosis, Nf-Κb
UniProt ID	[P50281](https://www.uniprot.org/uniprot/P50281)
NCBI Gene ID	4323
GeneCards	MMP14
Human Protein Atlas	MMP14
Propeptide domain	Maintains enzyme latency via cysteine switch
Catalytic domain	Contains zinc-binding motif (HELGH)
Hemopexin-like domain	Mediates substrate recognition
Transmembrane domain	Anchors protein to cell membrane
Cytoplasmic tail	Regulates intracellular trafficking[@strongin1995]
Neuroinflammation	Upregulated in reactive astrocytes around amyloid plaques, contributing to inflammatory milieu.[@wilcock2011]
Associated Diseases	neurodegeneration
Interactions	AND, APOPTOSIS, INFLAMMATION, MMP9, TNF, TNF-Α
KG Connections	33 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph