protein

MTCH2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTCH2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

8Outgoing

3Incoming

0Experiments

Summary

MTCH2 is a protein involved in neurodegeneration research. Key relationships include: regulates, binds, interacts with. Associated with Als. Connected to 12 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	MTCH2
Full Name	Mitochondrial Carrier Homolog 2
Chromosome	11p15.4
Function	MTCH2 is a phylogenetically conserved protein that localizes to the outer mitochondrial membrane
Molecular Weight	35 kDa
Amino Acids	303 aa
Pathways	Apoptosis, Stem Cell
UniProt ID	[Q9Y6C9](https://www.uniprot.org/uniprot/Q9Y6C9)
Ensembl ID	ENSG00000135249
OMIM	614215
GeneCards	MTCH2
Human Protein Atlas	MTCH2
Serves as insertase	Functions as a mitochondrial outer membrane insertase for proteins [@gonzalez2025]
Regulates mitophagy	Controls mitophagy initiation and mitochondrial quality control [@yang2025]
Interacts with Bcl-2 family	Associates with pro-apoptotic and anti-apoptotic proteins
Associated Diseases	neurodegeneration
Interactions	SelH
KG Connections	11 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MTCH2["<b>MTCH2</b>"]
    tBID["tBID"]
    MTCH2 -->|"binds"| tBID
    neurodegeneration["neurodegeneration"]
    MTCH2 -->|"implicated in"| neurodegeneration
    tBID -->|"binds"| MTCH2
    Cucurbitacin_B["Cucurbitacin B"]
    Cucurbitacin_B -->|"binds"| MTCH2
    SelH["SelH"]
    SelH -->|"interacts with"| MTCH2
    style MTCH2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
tBID	binds	protein	0.80
Als	regulates	disease	0.65
BID	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
BCL-2	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60
Stem Cell	regulates	pathway	0.60

Incoming (3)

Source	Relation	Type	Str
tBID	binds	protein	0.90
Cucurbitacin B	binds	chemical	0.80
SelH	interacts_with	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MTCH2

Understanding Entity Pages

Summary

Wiki Pages (6)

MTCH2 — Mitochondrial Carrier Homolog 2

FGF13-MTCH2 Neuroprotection in Parkinson's Disease

NLR Family Member X1

MTCH2 Protein

Proteins