gene

BID

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BID: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

355Connections

0Hypotheses

6Analyses

50Outgoing

50Incoming

Summary

Pro-apoptotic BCL2 family protein linking extrinsic and intrinsic apoptosis pathways in neurodegeneration

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🧬 Gene Info

Gene Symbol	BID
Full Name	BH3 Interacting Domain Death Agonist
Chromosome	22q11.21
Protein Family	BCL2 family, BH3-only proteins
Function	is a relatively inactive cytosolic protein.
Molecular Weight	22 kDa
Amino Acids	195 aa
Pathways	Apoptosis, Stem Cell
UniProt ID	P55957
NCBI Gene ID	637
Ensembl ID	ENSG00000105619
OMIM	603678
GeneCards	BID
Human Protein Atlas	BID
N-terminal region	Contains caspase-8 cleavage sites (D75, D81)
Associated Diseases	ALS, Aging, Alzheimer, Inflammation, Neurodegeneration
Interactions	MTOR, BAD, AKT, BAX, CYP2D6, CYP3A4
KG Connections	355 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BID — AlphaFold P55957 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BID["BID"]
    BID -->|"target for"| Parkinson["Parkinson"]
    BID -->|"target for"| Inflammation["Inflammation"]
    BID -->|"activates"| Tumor["Tumor"]
    BID -->|"activates"| Als["Als"]
    BID -->|"target for"| Neurodegeneration["Neurodegeneration"]
    BID -->|"target for"| Aging["Aging"]
    BID -->|"target for"| Alzheimer["Alzheimer"]
    IFN__["IFN-gamma"] -->|"contributes to"| BID
    IFN_gamma["IFN-gamma"] -->|"contributes to"| BID
    TLR2["TLR2"] -->|"target for"| BID
    MTOR["MTOR"] -->|"target for"| BID
    PLA2G6["PLA2G6"] -->|"target for"| BID
    PANK2["PANK2"] -->|"target for"| BID
    MAX["MAX"] -->|"target for"| BID
    GENES["GENES"] -->|"target for"| BID
    ERK["ERK"] -->|"target for"| BID
    BAX["BAX"] -->|"activates"| BID

Outgoing (249)

Target	Relation	Type	Str
Oxidative Stress	mediates	process	0.90
apoptosis	mediates	process	0.85
Mitochondria	participates_in	entity	0.80
Apoptosis	involved_in	process	0.80
Tumor	activates	disease	0.75
Als	regulates	disease	0.75
Apoptosis	activates	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
Spinal Muscular Atrophy	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	contributes_to	disease	0.65
Ms	activates	disease	0.65
Ataxia	regulates	disease	0.65
ALS	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Tumor	causes	disease	0.65
ALS	causes	disease	0.65
Cancer	activates	disease	0.65
Melanoma	activates	disease	0.65
Als	causes	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	causes	disease	0.65
Alzheimer	causes	disease	0.65
Aging	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Frontotemporal Dementia	expressed_in	disease	0.65
Ferroptosis	expressed_in	disease	0.65
Aging	encodes	disease	0.65
Frontotemporal Dementia	encodes	disease	0.65
Dementia	encodes	disease	0.65
Amyotrophic Lateral Sclerosis	encodes	disease	0.65
Als	encodes	disease	0.65
OXIDATIVE_STRESS	causes	phenotype	0.64
BAD	associated_with	gene	0.60
BAK1	associated_with	gene	0.60
BAX	associated_with	gene	0.60
MTOR	activates	gene	0.60
LAMP2	associated_with	gene	0.60

Incoming (106)

Source	Relation	Type	Str
IFN-γ	contributes_to	protein	0.80
IFN-gamma	contributes_to	protein	0.80
BAX	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
LAMP2	associated_with	gene	0.60
TFRC	associated_with	gene	0.60
PPP1CB	associated_with	gene	0.60
TLR2	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
PLA2G6	therapeutic_target	gene	0.60
PANK2	therapeutic_target	gene	0.60
MAX	therapeutic_target	gene	0.60
TRKB	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
BAK1	associated_with	gene	0.60
BAX	associated_with	gene	0.60
BAD	activates	gene	0.60
AKT	therapeutic_target	gene	0.60
SMAC	activates	gene	0.60
MTOR	activates	gene	0.60
BAD	associated_with	gene	0.60
MTOR	causes	gene	0.60
BAX	causes	gene	0.60
BAK1	causes	gene	0.60
MTCH2	regulates	gene	0.60
PTEN	activates	gene	0.60
TAU	therapeutic_target	gene	0.60
JNK	therapeutic_target	gene	0.60
ATM	regulates	gene	0.60
ATR	regulates	gene	0.60
BAD	degrades	entity	0.60
ATXN2	expressed_in	gene	0.60
HNRNPA1	expressed_in	gene	0.60
CNTN4	expressed_in	gene	0.60
PLIN4	expressed_in	gene	0.60
TBC1D24	expressed_in	gene	0.60
FUS	expressed_in	gene	0.60
HNRNPA2B1	expressed_in	gene	0.60
TRKB	causes	gene	0.60
JNK	causes	gene	0.60
AKT	causes	gene	0.60
FUS	encodes	gene	0.60
PLIN4	encodes	gene	0.60
HNRNPA2B1	encodes	gene	0.60
ATXN2	encodes	gene	0.60
HNRNPA1	encodes	gene	0.60
CNTN4	encodes	gene	0.60
SMN	encodes	gene	0.60
CCNF	encodes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (6)

Scientific analyses that reference this entity

What is the temporal sequence of sleep disruption versus amyloid-beta accumulati

neurodegeneration | 2026-04-12 | 0 hypotheses

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

neuroinflammation | 2026-04-08 | 0 hypotheses

What are the specific molecular mechanisms by which C1Q components drive atheros

neuroinflammation | 2026-04-07 | 0 hypotheses

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

neurodegeneration | 2026-04-02 | 0 hypotheses

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

neurodegeneration | 2026-04-02 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BID

Understanding Entity Pages

Summary

Wiki Pages (21)

BID — BH3 Interacting Domain Death Agonist

cbs-psp-daily-action-plan

Clinical Management Guide for CBS/PSP

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

nhp-validation-animal-model

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Coenzyme Q10 for Neurodegeneration

deferiprone-neurodegeneration

dimethyl-fumarate-nrf2-ad-nct06850597

Excitotoxicity in Neurodegeneration

NACET (N-Acetylcysteine Ethyl Ester)

Curcumin for Neurodegeneration

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

tudca-udca-neurodegeneration

nfl-blood-test-guided-therapy

Rotigotine and Rivastigmine Combination Therapy for Alzheimer's Disease (NCT06702124)

Parkinson's Disease Treatment

Corticobasal Degeneration (CBD) Treatment

KarXT+EC Phase 3 (NCT07011732): Enhanced Formulation for AD Agitation

Cytochrome c Protein

nct07322003

Pathway Diagram

Outgoing (249)

Incoming (106)

Targeting Hypotheses (0)

Mentioning Analyses (6)

What is the temporal sequence of sleep disruption versus amyloid-beta accumulati

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

What are the specific molecular mechanisms by which C1Q components drive atheros

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

GBA-Synuclein Loop Therapeutics for PD

Related Papers (0)