mechanism 1,710 words KG: ent-gene-3bc26681 2026-03-26
kind:mechanismsection:mechanismsstate:publishedtopic:parkinsonstopic:mitochondriatopic:neuroprotectiontopic:FGFtopic:MTCH2
Contents

FGF13-MTCH2 Neuroprotection in Parkinson's Disease

🔬 Protein Info
Gene SymbolFGF13
Full NameMTCH2 Neuroprotection in Parkinson's Disease
AliasesGene profile: FGF13
ChromosomeXq26.3
Protein TypeChannel
Functionis a member of the FGF family that is predominantly expressed in neuronal tissues, distinguishing it from many other FGFs with broader expression patterns.
Primary Expressionneuronal tissues, distinguishing it from many other FGFs with broader expression patterns
Subcellular Localizationthe cytoplasm and nucleus
PathwaysCalcium Signaling
UniProt IDP15532
NCBI Gene ID2253
GeneCardsFGF13
Human Protein AtlasFGF13
Intracellular localizationFGF13 is primarily localized in the cytoplasm and nucleus
Voltage-gated sodium channel modulationFGF13 binds to and modulates NaV1.2/NaV1.6 sodium channels[@fgf13_channel], regulating neuronal excitability
Associated DiseasesInflammation
InteractionsCDK5R2, SLC17A7, GRM5, ISG15, SCN2B, SCN8A
KG Connections62 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Microbial Inflammasome Priming Prevention
Score: 0.58
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming
Score: 0.61
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S
Score: 0.60
Membrane Cholesterol Gradient Modulators
Score: 0.52

Related Analyses (30)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (30)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-3bc26681 data_in benchmark_ot_ad_answer_key:FGF13
benchmark_ot_ad_answer_key:FGF13 data_in ent-gene-3bc26681