gene

NDUFAF4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFAF4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

3Outgoing

2Incoming

0Experiments

0Debates

Summary

NDUFAF4 is a mitochondrial complex I assembly factor essential for NADH dehydrogenase biogenesis. Mutations cause Leigh syndrome and mitochondrial complex I deficiency with relevance to neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	NDUFAF4
Full Name	NADH Dehydrogenase Complex Assembly Factor 4
Chromosome	12p13.33
Protein Type	Gene
Function	encodes a protein of approximately 20 kDa that localizes to the mitochondrial matrix.
Molecular Weight	20 kDa
Amino Acids	177 aa
Exons	6
UniProt ID	Q9NX63
NCBI Gene ID	55728
Ensembl ID	ENSG00000123545
GeneCards	NDUFAF4
Human Protein Atlas	NDUFAF4
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
Interactions	MITOCHONDRIAL DYSFUNCTION, MYC
KG Connections	5 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NDUFAF4 — AlphaFold Q9NX63 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NDUFAF4 — NADH Dehydrogenase Complex Assembly Factor 4

gene · 1704 words

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Pathway Diagram

flowchart TD
    NDUFAF4(["NDUFAF4"])
    Tumor["Tumor"]
    Cancer["Cancer"]
    MYC(["MYC"])
    MITOCHONDRIAL_DYSFUNCTION(["MITOCHONDRIAL DYSFUNCTION"])
    CANCER(["CANCER"])
    neurodegeneration["neurodegeneration"]

    NDUFAF4 -->|"therapeutic target"| Tumor
    NDUFAF4 -->|"therapeutic target"| Cancer
    NDUFAF4 -->|"activates"| MYC
    MITOCHONDRIAL_DYSFUNCTION -->|"activates"| NDUFAF4
    CANCER -->|"therapeutic target"| NDUFAF4
    NDUFAF4 -->|"implicated in"| neurodegeneration

    style NDUFAF4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (3)

Target	Relation	Type	Str
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
MYC	activates	gene	0.60

Incoming (2)

Source	Relation	Type	Str
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NDUFAF4 in their description or question text

No additional research found