entity

NMO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NMO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

2Hypotheses

1Analyses

1Outgoing

12Incoming

0Experiments

2Debates

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Wiki Pages (2)

Knowledge base pages for this entity

Neuromyelitis Optica Spectrum Disorder (NMOSD)

disease · 3198 words

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Neuromyelitis Optica Spectrum Disorder (NMOSD)

disease · 746 words

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Outgoing (1)

Target	Relation	Type	Str
Anti-AQP4 autoantibodies	associated_with	biomarker	0.90

Incoming (12)

Source	Relation	Type	Str
AQP4	therapeutic_target_for	protein	0.90
Failure of B cell tolerance mechanisms	causes	process	0.90
C3	contributes_to	protein	0.79
B cell tolerance mechanisms	protective_against	mechanism	0.70
FcγRIIB	therapeutic_target_for	protein	0.70
FCGR2B	protective_against	gene	0.70
B cell tolerance defects	risk_factor_for	mechanism	0.70
Breg frequency reduction	associated_with	biomarker	0.70
AQP4-specific B cells	causes	cell_type	0.70
MAP1B	implicated_in	gene	0.50
MAP2	implicated_in	gene	0.50
MAP6	implicated_in	gene	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Combine Anti-AQP4 Autoimmunity Control with Astrocyte-Endfoo	0.630	neurodegeneration	How can AQP4 be effectively targeted the
AQP4 Autoantibodies in NMOSD Cause Bystander Oligodendrocyte	0.560	neurodegeneration	What are the specific molecular mechanis

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do B cells mechanistically orchestrate tolerance to AQP4 and prevent autoimm

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.738

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The title suggests B cells actively maintain tolerance to AQP4, but the specific

closed · Rounds: 4 · Score: 0.66 · 2026-04-13

The title suggests B cells actively maintain tolerance to AQP4, but the specific

closed · Rounds: 4 · Score: 0.79 · 2026-04-13

Related Research

Hypotheses and analyses mentioning NMO in their description or question text

No additional research found