gene

MAP1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections
0Hypotheses
0Analyses
50Outgoing
11Incoming

Summary

MAP1B is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in, contributes to. Associated with AD, ALI, ALS. Connected to 29 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolMAP1B
Full NameMicrotubule Associated Protein 1B
AliasesMicrotubule-Associated Protein 1B
Chromosome5q13.2
Protein FamilyMAP1 family
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressiondeveloping neurons
Subcellular LocalizationAxons, growth cones, synaptic terminals, dendrites
Molecular Weight300 kDa
Amino Acids2700 aa
PathwaysAutophagy, NF-kB signaling
UniProt IDP46821
GeneCardsMAP1B
Human Protein AtlasMAP1B
Associated DiseasesAD, ALI, AMI, Als, NMO, RA
InteractionsMAP6, MAP2, UBIQUITIN, LC3, TAU, SAP97
KG Connections63 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: MAP1B — AlphaFold P46821 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

MAP1B Gene

gene · 866 words

nimodipine-als

clinical_trial · 5778 words

MACF1 — Microtubule-actin crosslinking factor 1

gene · 4087 words

amiloride-als

clinical_trial · 3477 words

Amyotrophic Lateral Sclerosis (ALS)

disease · 3458 words

MAPK9 Gene

gene · 3305 words

Pathway Diagram

graph TD
    MAP1B["<b>MAP1B</b>"]
    Als{"Als"}
    MAP1B -->|"interacts with"| Als
    ALS{"ALS"}
    MAP1B -->|"interacts with"| ALS
    MAP6["MAP6"]
    MAP1B -->|"interacts with"| MAP6
    Synaptic_Plasticity(["Synaptic Plasticity"])
    MAP1B -->|"contributes to"| Synaptic_Plasticity
    MAP2["MAP2"]
    MAP1B -->|"interacts with"| MAP2
    MAP1B -->|"associated with"| Synaptic_Plasticity
    GABARAP["GABARAP"]
    MAP1B -->|"regulates"| GABARAP
    UBIQUITIN["UBIQUITIN"]
    MAP1B -->|"interacts with"| UBIQUITIN
    NBR1["NBR1"]
    MAP1B -->|"associated with"| NBR1
    AUTOPHAGY["AUTOPHAGY"]
    MAP1B -->|"activates"| AUTOPHAGY
    LC3["LC3"]
    MAP1B -->|"interacts with"| LC3
    Autophagy(["Autophagy"])
    MAP1B -->|"activates"| Autophagy
    MAP2 -->|"interacts with"| MAP1B
    MAP6 -->|"interacts with"| MAP1B
    AND["AND"]
    AND -->|"interacts with"| MAP1B
    NEURON["NEURON"]
    NEURON -->|"contributes to"| MAP1B
    MICROTUBULES["MICROTUBULES"]
    MICROTUBULES -->|"contributes to"| MAP1B
    TAU["TAU"]
    TAU -->|"interacts with"| MAP1B
    style MAP1B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (52)

TargetRelationTypeStr
Microtubuleassociated_withprocess0.90
Alsinteracts_withdisease0.65
ALSinteracts_withdisease0.65
Neuropathytransportsdisease0.65
MAP6interacts_withgene0.60

Incoming (11)

SourceRelationTypeStr
MAP2interacts_withgene0.60
MAP6interacts_withgene0.60
TAUinteracts_withgene0.60
TRKAtransportsgene0.60
RETtransportsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found