gene

MAP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

392Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

MAP2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with AD, ALI, ALS. Connected to 129 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAP2
Full Name	Microtubule Associated Protein 2
Aliases	Microtubule-Associated Protein 2
Protein Type	Protein
Function	is a neuronal cytoskeletal protein that plays essential roles in dendritic arborization, synaptic stability, and microtubule stabilization in neurons[@dehmelt2003].
Primary Expression	neuronal cell bodies and dendrites, where it serves as a critical organizer of the dendritic cytoskeleton[@binder1985]
Subcellular Localization	dendrites. It plays critical roles in dendritic architecture, synaptic plasticity, microtubule stabilization, and intrac
Molecular Weight	280 kDa
Pathways	Apoptosis, Autophagy, Dna Methylation, Epigenetic, Glycolysis
UniProt ID	Search UniProt
GeneCards	MAP2
Human Protein Atlas	MAP2
Associated Diseases	AD, ALI, ALS, AMI, Aging
Known Drugs/Compounds	rapamycin
Interactions	MAP1B, MAP6, ACTB, ATG7, ESR1, ESR2
KG Connections	392 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MAP2 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAP2["MAP2"] -->|"interacts"| Als["Als"]
    MAP2["MAP2"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    MAP2["MAP2"] -->|"activates"| Alzheimer["Alzheimer"]
    MAP2["MAP2"] -->|"activates"| Ms["Ms"]
    MAP2["MAP2"] -->|"activates"| Ischemia["Ischemia"]
    MAP2["MAP2"] -->|"activates"| Als_1["Als"]
    ACTB["ACTB"] -->|"activates"| MAP2["MAP2"]
    LAMP1["LAMP1"] -->|"associated"| MAP2["MAP2"]
    MTOR["MTOR"] -->|"associated"| MAP2["MAP2"]
    LC3["LC3"] -->|"associated"| MAP2["MAP2"]
    style MAP2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (240)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Microtubule	associated_with	process	0.90
oxidative stress response	participates_in	pathway	0.70
neurons	expressed_in	cell_type	0.70
Als	interacts_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Ischemia	activates	disease	0.65
Als	activates	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Ms	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neuroblastoma	biomarker_for	disease	0.65
Neuropathy	protects_against	disease	0.65
Diabetes	protects_against	disease	0.65
Als	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Type 2 Diabetes	protects_against	disease	0.65
Insulin Resistance	biomarker_for	disease	0.65
Dementia	protects_against	disease	0.65
Stroke	activates	disease	0.65
Ischemia	causes	disease	0.65
Stroke	causes	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
ALS	associated_with	disease	0.65
MAP1B	interacts_with	gene	0.60
MAP6	interacts_with	gene	0.60
SYN1	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
SNAP25	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
SYT1	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
LC3	associated_with	gene	0.60
ACTB	activates	gene	0.60
ATG7	activates	gene	0.60
ESR1	activates	gene	0.60
ESR2	activates	gene	0.60

Incoming (152)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
ACTB	activates	gene	0.60
LAMP1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
LC3	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
ATG7	activates	gene	0.60
JUN	activates	gene	0.60
SQSTM1	associated_with	gene	0.60
SYN1	associated_with	gene	0.60
P62	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MAP1B	interacts_with	gene	0.60
CXCR3	therapeutic_target	gene	0.60
MAP6	interacts_with	gene	0.60
TAU	interacts_with	gene	0.60
TUBULIN	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
SNAP25	associated_with	gene	0.60
SYT1	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
BAX	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
BCL2	biomarker_for	gene	0.60
GAP43	biomarker_for	gene	0.60
LAMP1	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
IBA1	activates	gene	0.60
CTSD	activates	gene	0.60
TFR1	regulates	gene	0.60
GPX4	regulates	gene	0.60
APOE	regulates	gene	0.60
FERROPORTIN	regulates	gene	0.60
HDAC2	activates	gene	0.60
BDNF	activates	gene	0.60
AKT	activates	gene	0.60
GFAP	causes	gene	0.60
TRKB	activates	gene	0.60
GFAP	activates	gene	0.60
BAG3	activates	gene	0.60
CD44	activates	gene	0.60
OCT4	inhibits	gene	0.60
LIMK1	inhibits	gene	0.60
PSD95	inhibits	gene	0.60
TAU	inhibits	gene	0.60
SOX2	inhibits	gene	0.60
CTSB	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MAP2

Understanding Entity Pages

Summary

Wiki Pages (21)

MAP2 Gene

nimodipine-als

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

mitochondrial-dynamics-dysfunction-parkinsons

amiloride-als

Amyotrophic Lateral Sclerosis (ALS)

KDM3A Gene (JMJD1A)

SETD1B

Riluzole ALS Trials

msa-oligodendrocyte-pathology

Calcium Dysregulation in Neurodegenerative Diseases

Biomarkers of Alzheimer Disease

TUBB — Tubulin Beta Class I

viral-post-infectious-als

High-Dose Vitamins ALS Trial

AAV Gene Therapy Vectors for Neurodegeneration

Mechanism: Progranulin Loss and TDP-43 Pathology in FTD