NPAS3

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPAS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NPAS3 encodes a brain-specific transcription factor essential for neuronal development, synaptic plasticity, and cognitive function. Implicated in Alzheimer's disease, schizophrenia, and intellectual disability

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flowchart TD
    N0["NPAS3"]
    N1["Intellectual Disability"]
    N0 -->|"associated with"| N1
    N2["Schizophrenia"]
    N0 -->|"associated with"| N2
    N3["ARNT"]
    N0 -->|"binds"| N3
    N4["VGF"]
    N0 -->|"regulates"| N4
    N5["TXNIP"]
    N0 -->|"regulates"| N5
    N6["Alzheimer's Disease"]
    N0 -->|"associated with"| N6
    N7["Parkinson's Disease"]
    N0 -->|"associated with"| N7
    N8["Pulmonary Hypoplasia"]
    N0 -->|"causes"| N8
    N9["Congenital Diaphragmatic Hernia"]
    N0 -->|"downregulates"| N9
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N4 gene
    class N5 gene
    class N6 disease
    class N7 disease
    class N8 disease
    class N9 disease