gene 4,037 words KG: NPAS3 2026-03-27
kind:genesection:genesstate:publishedtopic:alzheimerstopic:transcription-factortopic:brain-developmenttopic:synaptic-plasticitytopic:cognition
Contents

NPAS3 Gene

🧬 Gene Info
Gene SymbolNPAS3
Full NameNeuronal PAS Domain Protein 3
Chromosome12q23.3
Protein TypeTranscription Factor
Functionencodes a brain-specific transcription factor belonging to the bHLH-PAS (basic Helix-Loop-Helix-Per-Arnt-Sim) family of transcriptional regulators.
Primary ExpressionBrain-specific (neurons)
Molecular Weight65 kDa
Amino Acids593 aa
Exons27
UniProt ID[Q8TDW5](https://www.uniprot.org/uniprot/Q8TDW5)
Ensembl IDENSG00000173137
GeneCardsNPAS3
Human Protein AtlasNPAS3
Associated DiseasesAlzheimer's Disease, Intellectual Disability, Parkinson's Disease, Pulmonary Hypoplasia, Schizophrenia
KG Connections9 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Circadian Clock-Autophagy Synchronization
Score: 0.55

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (4)

VGF — VGF Nerve Growth Factor Inducible
gene · KG edge: regulates
txnip
gene · KG edge: regulates
ARNT - Aryl Hydrocarbon Receptor Nuclear Translocator
gene · KG edge: binds
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (9 edges)

NPAS3 associated_with Intellectual Disability
NPAS3 regulates VGF
NPAS3 regulates TXNIP
NPAS3 causes Pulmonary Hypoplasia
NPAS3 downregulates Congenital Diaphragmatic Hernia
NPAS3 associated_with Schizophrenia
NPAS3 associated_with Alzheimer's Disease
NPAS3 associated_with Parkinson's Disease
NPAS3 binds ARNT