gene

VGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

118Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

VGF is a gene implicated in neurodegeneration research. Key relationships include: implicated in, associated with, biomarker for. Associated with AD, ALI, Als. Connected to 49 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolVGF
Full NameVGF Nerve Growth Factor Inducible
Chromosome7q22.1
Primary Expressionneurons of the central and peripheral nervous systems
Molecular Weight68 kDa
Amino Acids617 aa
PathwaysMAPK pathway, PI3K, AMPK pathway
UniProt IDQ9Y241
NCBI Gene ID9005
Ensembl IDENSG00000149716
OMIM607416
GeneCardsVGF
Human Protein AtlasVGF
RegionExpression Level
HypothalamusVery High
Associated DiseasesAD, ALI, Als, Alzheimer, Alzheimer'S Disease
InteractionsHDAC1, NTRK2, BDNF, NGF, CTSB, CTSD
KG Connections118 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: VGF — AlphaFold Q9UK23 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

VGF — VGF Nerve Growth Factor Inducible

gene · 1003 words

epas1-protein

protein · 2900 words

Geniposide for Alzheimer's disease - immune biomarker targeting and therapeutic potential

mechanism · 1885 words

MicroRNA Dysfunction in Neurodegeneration

mechanism · 1211 words

VAMP4 Gene

gene · 1164 words

VGF Protein — VGF Nerve Growth Factor Inducible

protein · 806 words

Pathway Diagram

graph TD
    VGF["<b>VGF</b>"]
    Alzheimer{"Alzheimer"}
    VGF -->|"biomarker for"| Alzheimer
    Ms{"Ms"}
    VGF -->|"biomarker for"| Ms
    VGF -->|"associated with"| Alzheimer
    VGF -->|"expressed in"| Ms
    Cancer{"Cancer"}
    VGF -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    VGF -->|"expressed in"| Tumor
    Schizophrenia{"Schizophrenia"}
    VGF -->|"expressed in"| Schizophrenia
    NTN1["NTN1"]
    VGF -->|"associated with"| NTN1
    GPNMB["GPNMB"]
    VGF -->|"associated with"| GPNMB
    NPTX2["NPTX2"]
    VGF -->|"associated with"| NPTX2
    Amyloid(["Amyloid"])
    VGF -->|"associated with"| Amyloid
    HDAC1["HDAC1"]
    VGF -->|"activates"| HDAC1
    GPNMB -->|"associated with"| VGF
    NPTX2 -->|"associated with"| VGF
    NTN1 -->|"associated with"| VGF
    CANCER["CANCER"]
    CANCER -->|"expressed in"| VGF
    HSPA1A["HSPA1A"]
    HSPA1A -->|"activates"| VGF
    PI3K["PI3K"]
    PI3K -->|"expressed in"| VGF
    AMYLOID["AMYLOID"]
    AMYLOID -->|"biomarker for"| VGF
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"biomarker for"| VGF
    style VGF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (67)

TargetRelationTypeStr
Alzheimer'S Diseaseassociated_withdisease0.85
ALZHEIMER'S DISEASEassociated_withentity0.80
Alzheimerbiomarker_fordisease0.65
Msbiomarker_fordisease0.65
Alzheimerassociated_withdisease0.65

Incoming (51)

SourceRelationTypeStr
NPAS3regulatesgene0.80
GPNMBassociated_withgene0.60
NPTX2associated_withgene0.60
NTN1associated_withgene0.60
HSPA1Aactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found