Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
VGF is a gene implicated in neurodegeneration research. Key relationships include: implicated in, associated with, biomarker for. Associated with AD, ALI, Als. Connected to 49 entities in the SciDEX knowledge graph.
| Gene Symbol | VGF |
| Full Name | VGF Nerve Growth Factor Inducible |
| Chromosome | 7q22.1 |
| Primary Expression | neurons of the central and peripheral nervous systems |
| Molecular Weight | 68 kDa |
| Amino Acids | 617 aa |
| Pathways | MAPK pathway, PI3K, AMPK pathway |
| UniProt ID | Q9Y241 |
| NCBI Gene ID | 9005 |
| Ensembl ID | ENSG00000149716 |
| OMIM | 607416 |
| GeneCards | VGF |
| Human Protein Atlas | VGF |
| Region | Expression Level |
| Hypothalamus | Very High |
| Associated Diseases | AD, ALI, Als, Alzheimer, Alzheimer'S Disease |
| Interactions | HDAC1, NTRK2, BDNF, NGF, CTSB, CTSD |
| KG Connections | 118 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
VGF["<b>VGF</b>"]
Alzheimer{"Alzheimer"}
VGF -->|"biomarker for"| Alzheimer
Ms{"Ms"}
VGF -->|"biomarker for"| Ms
VGF -->|"associated with"| Alzheimer
VGF -->|"expressed in"| Ms
Cancer{"Cancer"}
VGF -->|"expressed in"| Cancer
Tumor{"Tumor"}
VGF -->|"expressed in"| Tumor
Schizophrenia{"Schizophrenia"}
VGF -->|"expressed in"| Schizophrenia
NTN1["NTN1"]
VGF -->|"associated with"| NTN1
GPNMB["GPNMB"]
VGF -->|"associated with"| GPNMB
NPTX2["NPTX2"]
VGF -->|"associated with"| NPTX2
Amyloid(["Amyloid"])
VGF -->|"associated with"| Amyloid
HDAC1["HDAC1"]
VGF -->|"activates"| HDAC1
GPNMB -->|"associated with"| VGF
NPTX2 -->|"associated with"| VGF
NTN1 -->|"associated with"| VGF
CANCER["CANCER"]
CANCER -->|"expressed in"| VGF
HSPA1A["HSPA1A"]
HSPA1A -->|"activates"| VGF
PI3K["PI3K"]
PI3K -->|"expressed in"| VGF
AMYLOID["AMYLOID"]
AMYLOID -->|"biomarker for"| VGF
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"biomarker for"| VGF
style VGF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer'S Disease | associated_with | disease | 0.85 |
| ALZHEIMER'S DISEASE | associated_with | entity | 0.80 |
| Alzheimer | biomarker_for | disease | 0.65 |
| Ms | biomarker_for | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Schizophrenia | expressed_in | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Glioblastoma | activates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Depression | inhibits | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| NTN1 | associated_with | gene | 0.60 |
| GPNMB | associated_with | gene | 0.60 |
| NPTX2 | associated_with | gene | 0.60 |
| HDAC1 | activates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| DISC1 | regulates | gene | 0.60 |
| NTRK2 | activates | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| NGF | activates | gene | 0.60 |
| BDNF | regulates | gene | 0.60 |
| VEGF | regulates | gene | 0.60 |
| CTSB | inhibits | gene | 0.60 |
| CTSD | inhibits | gene | 0.60 |
| Rb | biomarker_for | protein | 0.60 |
| neurodegeneration | biomarker_for | disease | 0.60 |
| Amyloid | associated_with | pathway | 0.60 |
| Akt | regulates | pathway | 0.60 |
| Pi3K | expressed_in | pathway | 0.60 |
| ALZHEIMER | biomarker_for | gene | 0.60 |
| PTN | associated_with | gene | 0.60 |
| Amyloid | biomarker_for | pathway | 0.60 |
| ALZHEIMER'S DISEASE | biomarker_for | gene | 0.60 |
| AMYLOID | biomarker_for | gene | 0.60 |
| GLIOBLASTOMA | activates | gene | 0.60 |
| Stem Cell | expressed_in | pathway | 0.60 |
| Epigenetic | regulates | pathway | 0.60 |
| DEPRESSION | inhibits | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | regulates | gene | 0.60 |
| EXERCISE | activates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| Neurotrophin Signaling | inhibits | pathway | 0.60 |
| Neurogenesis | inhibits | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NPAS3 | regulates | gene | 0.80 |
| GPNMB | associated_with | gene | 0.60 |
| NPTX2 | associated_with | gene | 0.60 |
| NTN1 | associated_with | gene | 0.60 |
| HSPA1A | activates | gene | 0.60 |
| PI3K | expressed_in | gene | 0.60 |
| CST3 | inhibits | gene | 0.60 |
| CTSS | inhibits | gene | 0.60 |
| NPTX1 | regulates | gene | 0.60 |
| SERPINA3 | inhibits | gene | 0.60 |
| NRXN2 | regulates | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| PIN1 | associated_with | gene | 0.60 |
| RPL24 | associated_with | gene | 0.60 |
| CD44 | associated_with | gene | 0.60 |
| RPS23 | associated_with | gene | 0.60 |
| GFAP | expressed_in | gene | 0.60 |
| MYT1L | associated_with | gene | 0.60 |
| APP | expressed_in | gene | 0.60 |
| GPNMB | interacts_with | gene | 0.60 |
| NPTX2 | interacts_with | gene | 0.60 |
| NTN1 | interacts_with | gene | 0.60 |
| VAMP4 | associated_with | gene | 0.60 |
| VAMP7 | associated_with | gene | 0.60 |
| ATG5 | regulates | gene | 0.60 |
| VAMP2 | regulates | gene | 0.60 |
| LAMP1 | interacts_with | gene | 0.60 |
| LRRK2 | expressed_in | gene | 0.60 |
| VAMP4 | expressed_in | gene | 0.60 |
| VAMP7 | expressed_in | gene | 0.60 |
| LRRK2 | regulates | gene | 0.60 |
| VAMP4 | regulates | gene | 0.60 |
| VAMP7 | regulates | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| AMYLOID | biomarker_for | gene | 0.60 |
| ALZHEIMER'S DISEASE | biomarker_for | gene | 0.60 |
| ALZHEIMER | biomarker_for | gene | 0.60 |
| PTN | associated_with | gene | 0.60 |
| AMYLOID | inhibits | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| HSPB1 | expressed_in | gene | 0.60 |
| MITOCHONDRIA | associated_with | gene | 0.60 |
| MICROGLIA | associated_with | gene | 0.60 |
| MICRORNAS | associated_with | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| PTN | interacts_with | gene | 0.60 |
| GPNMB | co_discussed | protein | 0.50 |
| NPTX2 | co_discussed | protein | 0.50 |
| NTN1 | co_discussed | gene | 0.50 |
| ALZHEIMER | co_discussed | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||