gene

ARNT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARNT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

371Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ARNT is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, expressed in. Associated with ALS, Aging, Als. Connected to 196 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ARNT
Full Name	ARNT - Aryl Hydrocarbon Receptor Nuclear Translocator
Protein Type	Gene
Function	ARNT is an essential transcriptional cofactor
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Circadian Rhythm
NCBI Gene ID	Search NCBI
GeneCards	ARNT
Human Protein Atlas	ARNT
Associated Diseases	ALS, Aging, Alzheimer, Atherosclerosis, Cancer, Cardiac
Interactions	CLOCK, TNFRSF1A, ICAM1, AHR, OCLN, STAT6
KG Connections	371 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ARNT["ARNT"] -->|"expressed in"| Cancer["Cancer"]
    ARNT["ARNT"] -->|"expressed in"| Cardiovascular["Cardiovascular"]
    ARNT["ARNT"] -->|"expressed in"| Metabolic_Syndrome["Metabolic Syndrome"]
    ARNT["ARNT"] -->|"expressed in"| Obesity["Obesity"]
    ARNT["ARNT"] -->|"expressed in"| Ms["Ms"]
    ARNT["ARNT"] -->|"expressed in"| Diabetes["Diabetes"]
    AHR["AHR"] -->|"interacts"| ARNT["ARNT"]
    CRY["CRY"] -->|"expressed in"| ARNT["ARNT"]
    BMAL1["BMAL1"] -->|"expressed in"| ARNT["ARNT"]
    CLOCK["CLOCK"] -->|"expressed in"| ARNT["ARNT"]
    style ARNT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (247)

Target	Relation	Type	Str
circadian regulation	participates_in	pathway	0.75
Cancer	expressed_in	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Metabolic Syndrome	expressed_in	disease	0.65
Obesity	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Diabetes	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Cardiac	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Als	regulates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	associated_with	disease	0.65
Fibrosis	activates	disease	0.65
Autoimmune	regulates	disease	0.65
Hepatitis	regulates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Anxiety	activates	disease	0.65
Tumor	regulates	disease	0.65
Depression	activates	disease	0.65
Cancer	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Diabetes	activates	disease	0.65
Als	contributes_to	disease	0.65
Anxiety	contributes_to	disease	0.65
Depression	contributes_to	disease	0.65
Senescence	regulates	disease	0.65
Aging	regulates	disease	0.65
Cancer	regulates	disease	0.65
Lymphoma	inhibits	disease	0.65
Ischemia	inhibits	disease	0.65
Aging	expressed_in	disease	0.65
Obesity	activates	disease	0.65
Ms	activates	disease	0.65
Cardiovascular	activates	disease	0.65
ALS	inhibits	disease	0.65
ALS	regulates	disease	0.65
ALS	activates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Ischemia	regulates	disease	0.65
Cardiac	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65

Incoming (124)

Source	Relation	Type	Str
NPAS3	binds	protein	0.80
AHR	interacts_with	gene	0.64
BMAL1	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
CKB	inhibits	gene	0.60
BMAL1	regulates	gene	0.60
BCL2	inhibits	gene	0.60
BMAL1	activates	gene	0.60
CDK1	regulates	gene	0.60
BMAL1	associated_with	gene	0.60
CLOCK	associated_with	gene	0.60
JUNB	regulates	gene	0.60
CLOCK	activates	gene	0.60
CRY1	regulates	gene	0.60
CLDN1	inhibits	gene	0.60
NRF2	inhibits	gene	0.60
AKT	regulates	gene	0.60
TNF	regulates	gene	0.60
OCLN	regulates	gene	0.60
TNFRSF1A	activates	gene	0.60
AHR	activates	gene	0.60
OCLN	inhibits	gene	0.60
STAT6	activates	gene	0.60
YAP1	activates	gene	0.60
SLC7A11	activates	gene	0.60
GPX4	activates	gene	0.60
GAL	regulates	gene	0.60
TAZ	regulates	gene	0.60
CLOCK	regulates	gene	0.60
SOX2	regulates	gene	0.60
NESTIN	regulates	gene	0.60
MET	regulates	gene	0.60
BNIP3	inhibits	gene	0.60
AKT	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
RHOA	expressed_in	gene	0.60
MTOR	regulates	gene	0.60
FASN	regulates	gene	0.60
NAMPT	regulates	gene	0.60
PER2	regulates	gene	0.60
SIRT1	regulates	gene	0.60
ICAM1	activates	gene	0.60
JNK	expressed_in	gene	0.60
APP	activates	gene	0.60
SNAP29	activates	gene	0.60
P62	activates	gene	0.60
VAMP8	activates	gene	0.60
STX17	regulates	gene	0.60
GFAP	inhibits	gene	0.60
TAU	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ARNT

Understanding Entity Pages

Summary

Wiki Pages (21)

ARNT - Aryl Hydrocarbon Receptor Nuclear Translocator

NPAS3 Gene

Circadian Rhythm Modulation Therapy

Circadian Rhythm Dysfunction in Alzheimer's Disease

Circadian Rhythm Disruption in Neurodegeneration

epas1-protein

ARNTL Gene — Aryl Hydrocarbon Receptor Nuclear Translocator Like (BMAL1)

Circadian Clock Pathway in Neurodegeneration

HIF/Hypoxia Signaling in Parkinson's Disease

KCNH6 (Potassium Voltage-Gated Channel Subfamily H Member 6)

KCNH7 Gene

HIF-1α (Hypoxia-Inducible Factor 1-Alpha)

KCNIP3

ARNT2 - Aryl Hydrocarbon Receptor Nuclear Translocator 2

EGLN1 — Egl-9 Family Prolyl Hydroxylase 1

Suprachiasmatic Nucleus Neurons

HIF Signaling in Neurodegeneration

EPAS1 Gene

KCNH5 Gene