gene

ARNT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARNT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

363Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ARNT is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, expressed in. Associated with ALS, Aging, Als. Connected to 196 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ARNT
Full Name	Aryl Hydrocarbon Receptor Nuclear Translocator
Protein Type	Gene
Function	ARNT is an essential transcriptional cofactor
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Circadian Rhythm
GeneCards	ARNT
Human Protein Atlas	ARNT
Hypoxia response	Heterodimerizes with HIF1α and HIF2α to activate hypoxia-responsive genes
Circadian clock	Partners with CLOCK and BMAL1 in the circadian transcriptional complex
Xenobiotic response	Works with aryl hydrocarbon receptor (AHR)
Development	Critical for embryonic development, especially vascular formation
Associated Diseases	Aging, ALS, Alzheimer, Atherosclerosis, Cancer, Cardiac
Interactions	AHR, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ANXIETY
KG Connections	363 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ARNT["ARNT"] -->|"expressed in"| Cancer["Cancer"]
    ARNT["ARNT"] -->|"expressed in"| Cardiovascular["Cardiovascular"]
    ARNT["ARNT"] -->|"expressed in"| Metabolic_Syndrome["Metabolic Syndrome"]
    ARNT["ARNT"] -->|"expressed in"| Obesity["Obesity"]
    ARNT["ARNT"] -->|"expressed in"| Ms["Ms"]
    ARNT["ARNT"] -->|"expressed in"| Diabetes["Diabetes"]
    AHR["AHR"] -->|"interacts"| ARNT["ARNT"]
    CRY["CRY"] -->|"expressed in"| ARNT["ARNT"]
    BMAL1["BMAL1"] -->|"expressed in"| ARNT["ARNT"]
    CLOCK["CLOCK"] -->|"expressed in"| ARNT["ARNT"]
    style ARNT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (241)

Target	Relation	Type	Str
circadian regulation	participates_in	pathway	0.75
Cardiac	associated_with	disease	0.65
Obesity	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Cardiac	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	associated_with	disease	0.65
Fibrosis	activates	disease	0.65
Autoimmune	regulates	disease	0.65
Hepatitis	regulates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Als	contributes_to	disease	0.65
Anxiety	contributes_to	disease	0.65
Depression	contributes_to	disease	0.65
Senescence	regulates	disease	0.65
Aging	regulates	disease	0.65
Cancer	regulates	disease	0.65
Lymphoma	inhibits	disease	0.65
Ischemia	inhibits	disease	0.65
Aging	expressed_in	disease	0.65
Obesity	activates	disease	0.65
Ms	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Ischemia	regulates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Parkinson	associated_with	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Metabolic Syndrome	expressed_in	disease	0.65

Incoming (122)

Source	Relation	Type	Str
NPAS3	binds	protein	0.80
AHR	interacts_with	gene	0.64
CLOCK	expressed_in	gene	0.60
CKB	inhibits	gene	0.60
BMAL1	regulates	gene	0.60
BCL2	inhibits	gene	0.60
BMAL1	activates	gene	0.60
CDK1	regulates	gene	0.60
BMAL1	associated_with	gene	0.60
CLOCK	associated_with	gene	0.60
JUNB	regulates	gene	0.60
CLOCK	activates	gene	0.60
CRY1	regulates	gene	0.60
CLDN1	inhibits	gene	0.60
NRF2	inhibits	gene	0.60
YAP1	activates	gene	0.60
SLC7A11	activates	gene	0.60
GPX4	activates	gene	0.60
GAL	regulates	gene	0.60
TAZ	regulates	gene	0.60
CLOCK	regulates	gene	0.60
SOX2	regulates	gene	0.60
NESTIN	regulates	gene	0.60
MET	regulates	gene	0.60
BNIP3	inhibits	gene	0.60
AKT	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
RHOA	expressed_in	gene	0.60
MTOR	regulates	gene	0.60
FASN	regulates	gene	0.60
NAMPT	regulates	gene	0.60
PER2	regulates	gene	0.60
SIRT1	regulates	gene	0.60
GFAP	inhibits	gene	0.60
TAU	expressed_in	gene	0.60
GFAP	activates	gene	0.60
BDNF	expressed_in	gene	0.60
CRY2	expressed_in	gene	0.60
IBA1	activates	gene	0.60
GENES	expressed_in	gene	0.60
GENES	activates	gene	0.60
CCNA1	regulates	gene	0.60
ERK	regulates	gene	0.60
GENES	regulates	gene	0.60
CLDN4	inhibits	gene	0.60
FERROPTOSIS	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
AGING	regulates	gene	0.60
HIPPO	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ARNT in their description or question text

No additional research found