gene

pck2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about pck2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections
0Hypotheses
0Analyses
7Outgoing
2Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolPCK2
Chromosome14q12
Protein TypeGene
FunctionPhosphoenolpyruvate carboxykinase 2 (PCK2) is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP), a rate-limiting step in gluconeogenesis and anaplerosis
Primary Expressiontissues with high gluconeogenic activity including liver, kidney, and brain
Amino Acids640 aa
UniProt IDQ16822
GeneCardsPCK2
Human Protein AtlasPCK2
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: pck2 — AlphaFold Q16822 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

FOXO1 Protein

protein · 3787 words

KAT8 Gene

gene · 1073 words

FBP1 Gene

gene · 968 words

pck2

gene · 641 words

Genes

index · 271 words

Pathway Diagram

flowchart TD
    N0["PCK2"]
    N1["KAT8"]
    N1 -->|"lactylates"| N0
    N2["ferroptosis"]
    N0 -->|"promotes"| N2
    N3["PARKIN"]
    N0 -.->|"inhibits"| N3
    N4["AMPK"]
    N0 -->|"activates"| N4
    N5["MTOR"]
    N0 -->|"activates"| N5
    N6["Mtor"]
    N0 -->|"activates"| N6
    N7["Immune Response"]
    N0 -->|"activates"| N7
    N8["neurodegeneration"]
    N0 -->|"implicated in"| N8

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 protein
    class N3 protein
    class N4 gene
    class N5 gene
    class N6 pathway
    class N7 pathway

Outgoing (7)

TargetRelationTypeStr
ferroptosispromotesprocess0.93
PARKINinhibitsprotein0.92
MTORactivatesgene0.60
AMPKactivatesgene0.60
Mtoractivatespathway0.60

Incoming (2)

SourceRelationTypeStr
KAT8lactylatesprotein0.94
benchmark_ot_ad_answer_key:PCK2data_indataset_row0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found