Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about pck2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | PCK2 |
| Chromosome | 14q12 |
| Protein Type | Gene |
| Function | Phosphoenolpyruvate carboxykinase 2 (PCK2) is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP), a rate-limiting step in gluconeogenesis and anaplerosis |
| Primary Expression | tissues with high gluconeogenic activity including liver, kidney, and brain |
| Amino Acids | 640 aa |
| UniProt ID | Q16822 |
| GeneCards | PCK2 |
| Human Protein Atlas | PCK2 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["PCK2"]
N1["KAT8"]
N1 -->|"lactylates"| N0
N2["ferroptosis"]
N0 -->|"promotes"| N2
N3["PARKIN"]
N0 -.->|"inhibits"| N3
N4["AMPK"]
N0 -->|"activates"| N4
N5["MTOR"]
N0 -->|"activates"| N5
N6["Mtor"]
N0 -->|"activates"| N6
N7["Immune Response"]
N0 -->|"activates"| N7
N8["neurodegeneration"]
N0 -->|"implicated in"| N8
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 protein
class N3 protein
class N4 gene
class N5 gene
class N6 pathway
class N7 pathway| Target | Relation | Type | Str |
|---|---|---|---|
| ferroptosis | promotes | process | 0.93 |
| PARKIN | inhibits | protein | 0.92 |
| MTOR | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| Mtor | activates | pathway | 0.60 |
| Immune Response | activates | pathway | 0.60 |
| benchmark_ot_ad_answer_key:PCK2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| KAT8 | lactylates | protein | 0.94 |
| benchmark_ot_ad_answer_key:PCK2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||