gene

KAT8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KAT8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

210Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

KAT8 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in, regulates. Associated with Neurodegeneration, Parkinson, Tumor. Connected to 106 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	KAT8
Aliases	MOF, MYST1, YBL026W, KAT8, MOZ
Chromosome	16q24.1
Protein Type	Transferase
Function	KAT8/MOF is a highly conserved histone acetyltransferase belonging to the MYST family (MOZ, YBF2/SAS3, SAS2, TIP60).
Molecular Weight	52 kDa
Amino Acids	458 aa
Pathways	NF-κB
UniProt ID	Q9H7Z6
NCBI Gene ID	84144
Ensembl ID	ENSG00000103510
OMIM	609912
GeneCards	KAT8
Human Protein Atlas	KAT8
Gene Name	Lysine Acetyltransferase 8
Associated Diseases	Neurodegeneration, Parkinson, Tumor
Known Drugs/Compounds	rapamycin
Interactions	GAPDH, HDAC6, CREBBP, EP300, KAT2A, KAT5
KG Connections	210 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KAT8 — AlphaFold Q9H7Z6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KAT8["KAT8"]
    KAT8 -->|"implicated in"| neurodegeneration["neurodegeneration"]
    KAT8 ---|"associated"| Tumor["Tumor"]
    KAT8 ---|"associated"| Parkinson["Parkinson"]
    KAT8 ---|"associated"| RB1CC1["RB1CC1"]
    KAT8 ---|"associated"| SIRT1["SIRT1"]
    KAT8 ---|"associated"| LC3["LC3"]
    KAT8 ---|"associated"| SNAP29["SNAP29"]
    LYSOSOME["LYSOSOME"] -->|"regulates"| KAT8
    OPTN["OPTN"] ---|"associated"| KAT8
    ULK1["ULK1"] ---|"associated"| KAT8
    CALCOCO2["CALCOCO2"] ---|"associated"| KAT8
    HSPA8["HSPA8"] ---|"associated"| KAT8
    STX17["STX17"] ---|"associated"| KAT8
    SQSTM1["SQSTM1"] ---|"associated"| KAT8

Outgoing (128)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
PCK2	lactylates	protein	0.94
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Parkinson	implicated_in	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
Heart Failure	regulates	disease	0.65
RB1CC1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
RB1	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
EP300	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
TP53	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
RUBCN	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
STX17	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
OPTINEURIN	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
MAPT	implicated_in	gene	0.60
STX17	regulates	gene	0.60
KANSL1	regulates	gene	0.60
LAMP2A	activates	entity	0.60
MTOR	activates	entity	0.60
NBR1	activates	entity	0.60
NDP52	activates	entity	0.60
OPTINEURIN	activates	entity	0.60
OPTN	activates	entity	0.60
P62	activates	entity	0.60

Incoming (82)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
OPTN	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
STX17	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
EP300	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
RB1	associated_with	gene	0.60
P62	associated_with	gene	0.60
LC3	associated_with	gene	0.60
TP53	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
OPTINEURIN	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
RUBCN	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
PINK1	regulates	gene	0.60
KANSL1	regulates	gene	0.60
BECN1	activates	entity	0.60
CALCOCO2	activates	entity	0.60
CREBBP	activates	entity	0.60
EP300	activates	entity	0.60
FIP200	activates	entity	0.60
GAPDH	activates	entity	0.60
HDAC6	activates	entity	0.60
HSP70	activates	entity	0.60
HSPA8	activates	entity	0.60
KAT2A	activates	entity	0.60
KAT2B	activates	entity	0.60
KAT5	activates	entity	0.60
CBP	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KAT8

Understanding Entity Pages

Summary

Wiki Pages (12)

KAT8 Gene

Advanced Computational Neuroscience and AI-Driven Drug Discovery for CBS/PSP

Lactate Lactylation in Neurodegeneration

KAT6A Gene

kat6b

KAT8 Protein

KANSL1 — KAT8 Regulatory NSL Complex Subunit 1

pck2

KANSL1 Protein

EP300 Gene