gene

PELLINO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PELLINO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

7Outgoing

1Incoming

0Experiments

0Debates

Summary

PELI1 Gene

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	PELLINO1
Full Name	Pellino E3 Ubiquitin Protein Ligase 1
Chromosome	2p14
Protein Type	Ligase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Immune cells, brain (neurons, microglia)
Amino Acids	419 aa
Exons	10
UniProt ID	[Q9Y547](https://www.uniprot.org/uniprot/Q9Y547)
Ensembl ID	ENSG00000129128
GeneCards	PELLINO1
Human Protein Atlas	PELLINO1
TLR Signaling	Activated by TLR3, TLR4, TLR7, TLR8, and TLR9
IL-1R Signaling	Mediates IL-1β and IL-18 receptor signaling
TNFR Signaling	Participates in tumor necrosis factor receptor signaling
Associated Diseases	Cancer
KG Connections	8 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PELI1 Gene

gene · 973 words

→

Pathway Diagram

flowchart TD
    PELLINO1(["PELLINO1"])
    Tumor["Tumor"]
    Cancer["Cancer"]
    Als["Als"]
    Inflammation["Inflammation"]
    INFLAMMATION(["INFLAMMATION"])
    CANCER(["CANCER"])
    UBIQUITIN(["UBIQUITIN"])
    STAT3(["STAT3"])
    neurodegeneration["neurodegeneration"]

    PELLINO1 -->|"regulates"| Tumor
    PELLINO1 -->|"associated with"| Cancer
    PELLINO1 -->|"regulates"| Als
    PELLINO1 -->|"regulates"| Inflammation
    PELLINO1 -->|"regulates"| INFLAMMATION
    PELLINO1 -->|"associated with"| CANCER
    PELLINO1 -->|"regulates"| UBIQUITIN
    STAT3 -->|"regulates"| PELLINO1
    PELLINO1 -->|"implicated in"| neurodegeneration

    style PELLINO1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (7)

Target	Relation	Type	Str
Tumor	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Als	regulates	disease	0.65
Inflammation	regulates	disease	0.65
INFLAMMATION	regulates	gene	0.60
CANCER	associated_with	gene	0.60
UBIQUITIN	regulates	gene	0.60

Incoming (1)

Source	Relation	Type	Str
STAT3	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PELLINO1 in their description or question text

No additional research found