gene

PHF8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PHF8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

8Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for PHF8 (PHD Finger Protein 8)

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🧬 Gene Info

Gene Symbol	PHF8
Full Name	PHD Finger Protein 8
Chromosome	Xp11.22
Function	encodes a histone demethylase that removes mono- and dimethyl groups from histone H3 at lysine 9 (H3K9me1/2), histone H3 at lysine 27 (H3K27me2), and histone H4 at lysine 20 (H4K20me1).
Amino Acids	1024 aa
Pathways	Epigenetic
UniProt ID	[Q9UPP1](https://www.uniprot.org/uniprot/Q9UPP1)
Ensembl ID	ENSG00000172943
GeneCards	PHF8
Human Protein Atlas	PHF8
PHD finger	N-terminal zinc finger domain that specifically recognizes H3K4me3 (the activating promoter mark), tethering PHF8 to active gene promoters
JmjC domain	Catalytic Jumonji C domain that uses Fe(II) and 2-oxoglutarate as cofactors to oxidatively demethylate histone lysine residues
C-terminal region	Contains nuclear localization signals and mediates interactions with transcription factors
At gene bodies	PHF8 demethylates H3K9me2 to prevent spreading of heterochromatic silencing from adjacent repressive domains into active genes.
Cell cycle regulation	PHF8 demethylates H4K20me1 during the G1-S transition, regulating DNA replication licensing and cell cycle progression.
Associated Diseases	neurodegeneration
Interactions	AMYLOID, AUTOPHAGY, MTOR
KG Connections	8 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PHF8 (PHD Finger Protein 8)

gene · 1408 words

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Pathway Diagram

flowchart TD
    N0["PHF8"]
    N1["Neuropathy"]
    N0 -->|"activates"| N1
    N2["Als"]
    N0 -->|"regulates"| N2
    N3["AUTOPHAGY"]
    N0 -->|"activates"| N3
    N4["AMYLOID"]
    N0 -->|"activates"| N4
    N5["MTOR"]
    N0 -->|"activates"| N5
    N6["Mtor"]
    N0 -->|"activates"| N6
    N7["Autophagy"]
    N0 -->|"activates"| N7
    N8["Epigenetic"]
    N0 -->|"regulates"| N8
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 pathway
    class N7 pathway
    class N8 pathway

Outgoing (8)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Neuropathy	activates	disease	0.65
Epigenetic	regulates	pathway	0.60
AUTOPHAGY	activates	gene	0.60
Mtor	activates	pathway	0.60
Autophagy	activates	pathway	0.60
AMYLOID	activates	gene	0.60
MTOR	activates	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PHF8 in their description or question text

No additional research found