gene

PNOC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PNOC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections
0Hypotheses
0Analyses
19Outgoing
9Incoming

Summary

PNOC is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with ALS, Als, Diabetes. Connected to 19 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolPNOC
Full NamePNOC
Chromosome8p21
Protein TypeGene
Functionis a circuit and state modifier rather than a high-penetrance causative gene.
Molecular Weight20 kDa
Amino Acids17 aa
NCBI Gene IDSearch NCBI
GeneCardsPNOC
Human Protein AtlasPNOC
Associated DiseasesALS, Diabetes, Ms, OBESITY
KG Connections28 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

PNOC Gene

gene · 719 words

Nociceptin Receptor (NOP) Neurons

cell · 1085 words

PNOC Protein

protein · 993 words

Nociceptin Orphanin FQ Neurons

cell · 933 words

Bed Nucleus of the Stria Terminalis Dorsal Neurons

cell · 880 words

Nociceptin/Orphanin FQ (N/OFQ) Neurons

cell · 653 words

Pathway Diagram

graph TD
    PNOC["<b>PNOC</b>"]
    Als{"Als"}
    PNOC -->|"associated with"| Als
    Obesity{"Obesity"}
    PNOC -->|"therapeutic target"| Obesity
    Ms{"Ms"}
    PNOC -->|"associated with"| Ms
    Diabetes{"Diabetes"}
    PNOC -->|"associated with"| Diabetes
    PNOC -->|"associated with"| Obesity
    ALS{"ALS"}
    PNOC -->|"associated with"| ALS
    TRPC6["TRPC6"]
    PNOC -->|"therapeutic target"| TRPC6
    HCRTR1["HCRTR1"]
    PNOC -->|"therapeutic target"| HCRTR1
    GENES["GENES"]
    PNOC -->|"therapeutic target"| GENES
    HCRTR2["HCRTR2"]
    PNOC -->|"therapeutic target"| HCRTR2
    PNOC -->|"associated with"| HCRTR2
    AND["AND"]
    PNOC -->|"associated with"| AND
    HCRTR2 -->|"therapeutic target"| PNOC
    HCRTR1 -->|"therapeutic target"| PNOC
    HCRTR1 -->|"associated with"| PNOC
    GENES -->|"associated with"| PNOC
    TRPC6 -->|"associated with"| PNOC
    style PNOC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

TargetRelationTypeStr
Sleep Disordertherapeutic_targetdisease0.65
Alsassociated_withdisease0.65
Obesitytherapeutic_targetdisease0.65
Msassociated_withdisease0.65
Diabetesassociated_withdisease0.65

Incoming (9)

SourceRelationTypeStr
HCRTR2therapeutic_targetgene0.60
HCRTR1therapeutic_targetgene0.60
HCRTR1associated_withgene0.60
TRPC6associated_withgene0.60
HCRTR2associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found