Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PNOC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PNOC is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with ALS, Als, Diabetes. Connected to 19 entities in the SciDEX knowledge graph.
| Gene Symbol | PNOC |
| Full Name | PNOC |
| Chromosome | 8p21 |
| Protein Type | Gene |
| Function | is a circuit and state modifier rather than a high-penetrance causative gene. |
| Molecular Weight | 20 kDa |
| Amino Acids | 17 aa |
| NCBI Gene ID | Search NCBI |
| GeneCards | PNOC |
| Human Protein Atlas | PNOC |
| Associated Diseases | ALS, Diabetes, Ms, OBESITY |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
PNOC["<b>PNOC</b>"]
Als{"Als"}
PNOC -->|"associated with"| Als
Obesity{"Obesity"}
PNOC -->|"therapeutic target"| Obesity
Ms{"Ms"}
PNOC -->|"associated with"| Ms
Diabetes{"Diabetes"}
PNOC -->|"associated with"| Diabetes
PNOC -->|"associated with"| Obesity
ALS{"ALS"}
PNOC -->|"associated with"| ALS
TRPC6["TRPC6"]
PNOC -->|"therapeutic target"| TRPC6
HCRTR1["HCRTR1"]
PNOC -->|"therapeutic target"| HCRTR1
GENES["GENES"]
PNOC -->|"therapeutic target"| GENES
HCRTR2["HCRTR2"]
PNOC -->|"therapeutic target"| HCRTR2
PNOC -->|"associated with"| HCRTR2
AND["AND"]
PNOC -->|"associated with"| AND
HCRTR2 -->|"therapeutic target"| PNOC
HCRTR1 -->|"therapeutic target"| PNOC
HCRTR1 -->|"associated with"| PNOC
GENES -->|"associated with"| PNOC
TRPC6 -->|"associated with"| PNOC
style PNOC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Sleep Disorder | therapeutic_target | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Obesity | therapeutic_target | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Diabetes | associated_with | disease | 0.65 |
| Obesity | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| TRPC6 | therapeutic_target | gene | 0.60 |
| HCRTR1 | therapeutic_target | gene | 0.60 |
| HCRTR2 | therapeutic_target | gene | 0.60 |
| HCRTR2 | associated_with | gene | 0.60 |
| TRPC6 | associated_with | gene | 0.60 |
| HCRTR1 | associated_with | gene | 0.60 |
| TRPC6 | targets | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| App | associated_with | protein | 0.60 |
| OBESITY | associated_with | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||