concept

PUTAMEN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PUTAMEN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

58Connections

0Hypotheses

0Analyses

13Outgoing

24Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PUTAMEN
Key Genes/Proteins	C9orf72, TYROBP, SORL1, TH, STAT3, JAK2
Related Diseases	COGNITIVE DECLINE, DOPAMINE

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PUTAMEN["PUTAMEN"]
    TAU["TAU"] -->|"expressed in"| PUTAMEN
    PARKINSON["PARKINSON"] -->|"expressed in"| PUTAMEN
    HUNTINGTIN["HUNTINGTIN"] -->|"expressed in"| PUTAMEN
    CYP46A1["CYP46A1"] -->|"expressed in"| PUTAMEN
    HTT["HTT"] -->|"expressed in"| PUTAMEN
    HUNTINGTON["HUNTINGTON"] -->|"expressed in"| PUTAMEN
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| PUTAMEN
    SYNAPSE["SYNAPSE"] -->|"expressed in"| PUTAMEN

Outgoing (13)

Target	Relation	Type	Str
COGNITIVE DECLINE	interacts_with	phenotype	0.65
DOPAMINE	implicated_in	phenotype	0.55
FDG-PET	associated_with	biomarker	0.50
TH	associated_with	gene	0.50
STAT3	associated_with	gene	0.45
JAK2	associated_with	gene	0.45
GBA	associated_with	gene	0.45
TYROBP	associated_with	gene	0.45
SORL1	associated_with	gene	0.45
NEURON	associated_with	cell_type	0.45
SUBSTANTIA NIGRA	co_discussed	brain_region	0.40
THALAMUS	co_discussed	brain_region	0.40
WHITE MATTER	co_discussed	brain_region	0.40

Incoming (45)

Source	Relation	Type	Str
ASTROCYTE	activates	cell_type	0.65
C9orf72	interacts_with	gene	0.65
ASTROCYTES	treats	cell_type	0.65
TYROBP	activates	gene	0.65
SORL1	activates	gene	0.65
DOPAMINERGIC NEURONS	associated_with	cell_type	0.45
ALPHA-SYNUCLEIN	associated_with	protein	0.45
NEURONS	associated_with	cell_type	0.45
ASTROCYTES	associated_with	cell_type	0.45
ASTROCYTE	associated_with	cell_type	0.45
CYP46A1	associated_with	gene	0.45
HUNTINGTON'S DISEASE	associated_with	disease	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
PARKINSON'S DISEASE	associated_with	disease	0.45
DEMENTIA	associated_with	disease	0.45
C9orf72	associated_with	gene	0.45
MICROGLIA	associated_with	cell_type	0.45
DOPAMINE	associated_with	phenotype	0.45
COGNITIVE DECLINE	associated_with	phenotype	0.45
DOPAMINERGIC	co_discussed	cell_type	0.40
NEURON	co_discussed	cell_type	0.40
NEURONS	co_discussed	cell_type	0.40
BRAINSTEM	co_discussed	brain_region	0.40
CAUDATE	co_discussed	brain_region	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PUTAMEN

Understanding Entity Pages

Wiki Pages (21)

putamen

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Corticobasal Syndrome (CBS)

Parkinson's Disease

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Corticobasal Degeneration (CBD)

Multiple System Atrophy

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

gabaergic-dysfunction

CNTN6 — Contactin 6

Huntington's Disease

AI and Machine Learning in Neurodegeneration

Blood-Brain Barrier Biology and Crossing Strategies

Coenzyme Q10 for Neurodegeneration

substantia-nigra

deferiprone-neurodegeneration

psp-tauopathy

Mitochondrial Dysfunction in Neurodegeneration