gene

TYROBP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TYROBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

383Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

A gene referenced in 1 knowledge graph relationship. Key connections: encodes DAP12 (protein).

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🧬 Gene Info

Gene Symbol	TYROBP
Full Name	TYRO Binding Protein (DAP12)
Aliases	DAP12
Chromosome	19q13.12
Protein Type	Adaptor Protein
Function	is a transmembrane signaling adaptor protein that plays critical roles in innate immunity and microglial function in the central nervous system.
Primary Expression	Microglia, Monocytes, NK cells, Osteoclasts
Molecular Weight	12.1 kDa
Amino Acids	113 aa
Pathways	Innate Immunity
UniProt ID	Q9Y241
NCBI Gene ID	7305
Ensembl ID	ENSG00000111653
OMIM	605712
GeneCards	TYROBP
Human Protein Atlas	TYROBP
Associated Diseases	ALS, ALZHEIMER'S DISEASE, Aging, Alzheimer
Known Drugs/Compounds	BERBERINE
Interactions	RANK, OVERVIEW, TREM2, DAP12, APOE, SPI1
KG Connections	383 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TYROBP — AlphaFold Q9Y241 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TYROBP["TYROBP"] -->|"interacts"| TREM2["TREM2"]
    TYROBP["TYROBP"] -->|"expressed in"| microglia["microglia"]
    TYROBP["TYROBP"] -->|"interacts"| Alzheimer["Alzheimer"]
    TYROBP["TYROBP"] -->|"interacts"| Ms["Ms"]
    TYROBP["TYROBP"] -->|"activates"| Als["Als"]
    TYROBP["TYROBP"] -->|"associated"| Alzheimer_1["Alzheimer"]
    RANK["RANK"] -->|"activates"| TYROBP["TYROBP"]
    GENES["GENES"] -->|"activates"| TYROBP["TYROBP"]
    APP["APP"] -->|"associated"| TYROBP["TYROBP"]
    CD33["CD33"] -->|"associated"| TYROBP["TYROBP"]
    style TYROBP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (208)

Target	Relation	Type	Str
ds-db4a006ea647	provides_data_for	dataset	1.00
Late-Onset Alzheimer's Disease	associated_with	disease	0.95
SIRPΒ1	interacts_with	receptor	0.95
CR3	binds	receptor	0.95
SIRP1B	interacts_with	receptor	0.90
Brain Homeostasis	involved_in	process	0.90
Signal Transduction	mediates	process	0.90
Pathogen Phagocytosis	regulates	process	0.90
Gene Expression Changes	causes	phenotype	0.87
Molecular Interaction Networks	component_of	pathway	0.85
Disease-Associated Microglia	regulates	phenotype	0.85
C1Q	regulates	protein	0.85
tau phosphorylation	regulates	process	0.85
Alzheimer's Disease pathogenesis	mediates	mechanism	0.85
Alzheimer's Disease	associated_with	disease	0.85
Learning Behavior	regulates	phenotype	0.80
Synaptic Function	regulates	process	0.80
Immune Cell Infiltration	associated_with	process	0.80
Learning Behavior	involved_in	phenotype	0.75
Synaptic Function	involved_in	process	0.75
Als	activates	disease	0.75
Neurodegenerative Diseases	risk_factor_for	disease	0.75
TREM2	interacts_with	protein	0.72
microglia	expressed_in	cell_type	0.72
SYK	phosphorylates	gene	0.70
SYK	interacts_with	gene	0.70
neuroinflammation	activates	disease	0.70
NLRP3	inhibits	gene	0.65
NLRP3	treats	gene	0.65
TREM2	encodes	gene	0.65
TAU	exacerbates	protein	0.65
SYK	regulates	gene	0.65
STAT3	regulates	gene	0.65
STAT3	promotes	gene	0.65
Alzheimer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Tauopathy	expressed_in	disease	0.65
Aging	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Tumor	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Epilepsy	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Inflammation	activates	disease	0.65
ALS	activates	disease	0.65
Neuroinflammation	causes	disease	0.65
Inflammation	causes	disease	0.65

Incoming (175)

Source	Relation	Type	Str
ds-db4a006ea647	data_in	dataset	1.00
TREM2	interacts_with	entity	0.90
h-trem2-f3effd21	targets_gene	hypothesis	0.90
Immune and Microglia Module	associated_with	pathway	0.89
CD163	activates	gene	0.70
GENES	activates	gene	0.70
MICROGLIA	activates	gene	0.70
MICROGLIA	inhibits	cell_type	0.70
MICROGLIA	regulates	cell_type	0.70
DAP12	interacts_with	gene	0.65
GRN	activates	gene	0.65
MICROGLIA	produces	cell_type	0.65
BERBERINE	activates	drug	0.65
BERBERINE	regulates	drug	0.65
NEUROINFLAMMATION	regulates	phenotype	0.65
MICROGLIAL ACTIVATION	treats	phenotype	0.65
NEUROINFLAMMATION	protects_against	phenotype	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
ALZHEIMER'S DISEASE	targets	disease	0.65
RANK	activates	gene	0.60
APP	associated_with	gene	0.60
CD33	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
OVERVIEW	interacts_with	gene	0.60
PSEN1	associated_with	gene	0.60
TREM2	co_discussed	gene	0.60
CD33	co_discussed	gene	0.60
APP	co_discussed	gene	0.60
PSEN1	co_discussed	gene	0.60
TREM2	contributes_to	gene	0.60
C1Q	contributes_to	gene	0.60
DAP12	activates	gene	0.60
PSEN1	stabilizes	gene	0.60
APP	stabilizes	gene	0.60
TREM2	activates	gene	0.60
TAU	activates	gene	0.60
GAIN	activates	gene	0.60
STAT3	activates	gene	0.60
MMP12	activates	gene	0.60
CD33	activates	gene	0.60
RANK	regulates	entity	0.60
CD33	mediates	entity	0.60
TREM2	mediates	entity	0.60
RAMP1	associated_with	gene	0.60
C1QB	associated_with	gene	0.60
TMEM119	associated_with	gene	0.60
AIF1	associated_with	gene	0.60
APP	inhibits	gene	0.60
CSF1R	associated_with	gene	0.60
ITGAM	associated_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2 Signaling Bifurcation with Independent TYROBP-Independ	0.567	neuroinflammation	Why is TYROBP deficiency neuroprotective
SYK-Independent TREM2 Pathways Remain Functional in TYROBP D	0.555	neuroinflammation	Why is TYROBP deficiency neuroprotective

Mentioning Analyses (2)

Scientific analyses that reference this entity

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.567

Does SYK activation provide neuroprotection or exacerbate neuroinflammation in e

neurodegeneration | 2026-04-11 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TYROBP

Understanding Entity Pages

Summary

Wiki Pages (21)

TYROBP — TYRO Binding Protein (DAP12)

Alzheimer's Disease Mechanism Index

neuroinflammation

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

TREM2 Microglial Signaling Pathway in Neurodegeneration

TREM2→Microglial Dysfunction→Alzheimer's Disease Causal Chain

Gut-Microbiome-Neurodegeneration Axis

TREM2 in Frontotemporal Dementia

TREM2 Signaling in Neurodegeneration

al002-trem2-agonist-alzheimers

Neuroinflammation Microglia

Microglial Phagocytosis in Neurodegeneration

TREM2 in Parkinson's Disease — Cross-Disease Therapeutic Opportunity

Microglia Activation Mechanism

Neuroinflammation in Alzheimer's Disease

CSF1R Inhibitors for Parkinson's Disease

TREM2 in Amyotrophic Lateral Sclerosis

Vigil Neuroscience

putamen

PLCG2 Gene