concept

THALAMUS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about THALAMUS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

438Connections

0Hypotheses

0Analyses

34Outgoing

50Incoming

Summary

THALAMUS is a concept in neurodegeneration research. Key relationships include: co discussed, causes, associated with. Associated with PARKINSON'S DISEASE, STROKE. Connected to 20 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	THALAMUS
Summary	Page for Thalamus
Key Genes/Proteins	HTR1A, TAU, TFEB
Related Diseases	PARKINSON'S DISEASE, ANXIETY, CHRONIC TRAUMATIC ENCEPHALOPATHY, ALZHEIMER'S DISEASE

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Thalamus

brain · 1302 words

→

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    THALAMUS["<b>THALAMUS</b>"]
    HYPOTHALAMUS["HYPOTHALAMUS"] -->|"mediates"| THALAMUS
    RAPHE["RAPHE"] -->|"mediates"| THALAMUS
    APOPTOSIS["APOPTOSIS"] -->|"causes"| THALAMUS
    GLUTAMATERGIC["GLUTAMATERGIC"] -->|"causes"| THALAMUS
    STROKE["STROKE"] -->|"causes"| THALAMUS
    CLOCK["CLOCK"] -->|"expressed in"| THALAMUS
    CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"] -->|"expressed in"| THALAMUS
    CANCER["CANCER"] -->|"expressed in"| THALAMUS
    JUN["JUN"] -->|"expressed in"| THALAMUS
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"expressed in"| THALAMUS
    JAM2["JAM2"] -->|"expressed in"| THALAMUS

Outgoing (34)

Target	Relation	Type	Str
ANXIETY	causes	disease	0.65
WHITE MATTER	co_discussed	entity	0.50
WHITE MATTER	expressed_in	brain_region	0.50
CEREBELLUM	associated_with	concept	0.50
HYPOTHALAMUS	regulates	concept	0.50
NUCLEUS	regulates	concept	0.50
INTERNEURONS	activates	concept	0.50
GLUTAMATE	activates	concept	0.50
FRONTAL	activates	concept	0.50
AMYLOID-β	interacts_with	concept	0.50
CEREBRAL CORTEX	expressed_in	concept	0.50
HYPOTHALAMUS	expressed_in	concept	0.50
CEREBELLUM	expressed_in	concept	0.50
GLUTAMATE	associated_with	concept	0.50
NUCLEUS	associated_with	concept	0.50
NEURON	associated_with	cell_type	0.50
TNF	associated_with	gene	0.50
SLC1A2	associated_with	gene	0.45
APOE	associated_with	gene	0.45
AQP4	associated_with	gene	0.45
BIN1	associated_with	gene	0.45
WNT3A	associated_with	gene	0.45
LAMP1	associated_with	gene	0.45
SNCA	associated_with	gene	0.45
CTSD	associated_with	gene	0.45
CTSB	associated_with	gene	0.45
APP	associated_with	gene	0.45
GBA	associated_with	gene	0.45
TH	associated_with	gene	0.45
STING	associated_with	gene	0.45
CGAS	associated_with	gene	0.45
TFEB	associated_with	gene	0.45
GRN	associated_with	gene	0.45
TBK1	associated_with	gene	0.45

Incoming (404)

Source	Relation	Type	Str
PARKINSON'S DISEASE	associated_with	disease	0.66
HYPOTHALAMUS	regulates	brain_region	0.65
HTR1A	increases	gene	0.65
NEURON	causes	cell_type	0.65
NEURONS	causes	cell_type	0.65
HYPOTHALAMUS	increases	brain_region	0.65
CORTEX	expressed_in	brain_region	0.65
HYPOTHALAMUS	stabilizes	brain_region	0.65
TAU	phosphorylates	gene	0.65
TFEB	biomarker_for	gene	0.65
CHRONIC TRAUMATIC ENCEPHALOPATHY	produces	disease	0.65
ALZHEIMER'S DISEASE	associated_with	disease	0.64
HYPOTHALAMUS	associated_with	brain_region	0.60
HYPOTHALAMUS	mediates	brain_region	0.60
RAPHE	mediates	brain_region	0.60
HYPOTHALAMUS	causes	brain_region	0.60
GLUTAMATERGIC	causes	cell_type	0.60
STROKE	causes	disease	0.60
HYPOTHALAMUS	expressed_in	brain_region	0.60
HYPOTHALAMUS	interacts_with	brain_region	0.60
NEURON	treats	cell_type	0.60
NEURONS	treats	cell_type	0.60
ACHE	targets	gene	0.60
INTERNEURON	promotes	cell_type	0.60
INTERNEURONS	promotes	cell_type	0.60
NEURON	promotes	cell_type	0.60
NEURONS	promotes	cell_type	0.60
HYPOTHALAMUS	contributes_to	brain_region	0.60
ASTROCYTE	regulates	cell_type	0.60
RAPHE	impairs	brain_region	0.60
HYPOTHALAMUS	inhibits	brain_region	0.60
MICROGLIA	inhibits	cell_type	0.60
HYPOTHALAMUS	activates	brain_region	0.60
STING	expressed_in	gene	0.60
APOE	activates	gene	0.58
ASTROCYTES	regulates	cell_type	0.58
AMYLOID	regulates	protein	0.58
TAU	expressed_in	protein	0.58
ASTROCYTES	associated_with	cell_type	0.56
TARDBP	associated_with	gene	0.56
CIRCADIAN	co_discussed	entity	0.50
HYPOTHALAMUS	co_discussed	entity	0.50
CEREBELLUM	co_discussed	entity	0.50
NEURON	co_discussed	entity	0.50
NEURONS	co_discussed	entity	0.50
SUBSTANTIA NIGRA	co_discussed	entity	0.50
HIPPOCAMPUS	co_discussed	entity	0.50
GABA	co_discussed	entity	0.50
CEREBELLUM	expressed_in	brain_region	0.50
NEURON	activates	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

THALAMUS

Understanding Entity Pages

Summary

Wiki Pages (21)

Thalamus

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Corticobasal Syndrome (CBS)

Sleep and Circadian Dysfunction in Alzheimer's Disease

primary-progressive-aphasia

Device Therapies Comparison for CBS/PSP

calcium-dysregulation-comparison

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Corticobasal Degeneration (CBD)

GRIA3 Gene

CLCN10 — Chloride Voltage-Gated Channel 10

ncam2

Prion vs Tau/Alpha-Synuclein Propagation: Mechanistic Comparison

gabaergic-dysfunction

Huntington's Disease

Vascular Cognitive Impairment (VCI)

Vitamin D Signaling Pathway in Neurodegeneration

CNTN4 — Contactin 4