gene

RAD50

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAD50: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

1Hypotheses

1Analyses

4Outgoing

1Incoming

0Experiments

1Debates

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🧬 Gene Info

Gene Symbol	RAD50
Full Name	DNA Repair Protein RAD50
Chromosome	5q23.2
Protein Family	SMC family (Structural Maintenance of Chromosomes)
Function	encodes a crucial DNA repair protein that serves as the structural scaffold of the MRN complex (MRE11-RAD50-NBS1), which is essential for recognizing and repairing DNA double-strand breaks (DSBs).
Subcellular Localization	Nucleus (chromatin-associated)
Molecular Weight	180 kDa
Amino Acids	1586 aa
Gene Type	Protein coding
UniProt ID	Q9XQB3
NCBI Gene ID	10111
Ensembl ID	ENSG00000113522
OMIM	604040
GeneCards	RAD50
Human Protein Atlas	RAD50
Associated Diseases	neurodegeneration
Interactions	DRP1, RAD52, TBP
SciDEX Hypotheses	MRN Complex-PIC Interaction Disruptors
KG Connections	5 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RAD50 — AlphaFold Q9XQB3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RAD50 Gene

gene · 1522 words

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RAD50 Protein

protein · 1099 words

→

Pathway Diagram

graph TD
    RAD50["RAD50"]
    Aging["Aging"]
    RAD52["RAD52"]
    DRP1["DRP1"]
    neurodegeneration["neurodegeneration"]

    RAD50 -->|"interacts with"| Aging
    RAD50 -->|"interacts with"| RAD52
    DRP1 -->|"interacts with"| RAD50
    RAD50 -->|"implicated in"| neurodegeneration

    style RAD50 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Aging fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    style RAD52 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style DRP1 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff

Outgoing (4)

Target	Relation	Type	Str
TBP	interacts_with	protein	0.70
PIC_recruitment_to_DSBs	modulates	process	0.70
Aging	interacts_with	disease	0.65
RAD52	interacts_with	gene	0.60

Incoming (1)

Source	Relation	Type	Str
DRP1	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
MRN Complex-PIC Interaction Disruptors	0.000	-	How do dilncRNAs specifically drive mole

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do dilncRNAs specifically drive molecular crowding and phase separation of D

neurodegeneration | 2026-04-08 | 7 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract shows that dilncRNAs drive molecular crowding of DDR proteins into

closed · Rounds: 7 · Score: 0.90 · 2026-04-10

Related Research

Hypotheses and analyses mentioning RAD50 in their description or question text

No additional research found