Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | TBP |
| Full Name | TATA-Box Binding Protein |
| Chromosome | 6q27 |
| Protein Type | Transcription Factor |
| Function | is a general transcription factor essential for RNA polymerase II-mediated transcription initiation. |
| Amino Acids | 339 aa |
| Exons | 8 |
| Pathways | Amyloid |
| UniProt ID | P20226 |
| NCBI Gene ID | 6908 |
| Ensembl ID | ENSG00000112592 |
| OMIM | 600075 |
| GeneCards | TBP |
| Human Protein Atlas | TBP |
| Chr Location | 6q27 |
| Associated Diseases | neurodegeneration |
| Interactions | RELA, RHEB, SPI1, HNF4A, AXIN1, MYC |
| KG Connections | 56 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TBP["TBP"]
Als["Als"]
Ms["Ms"]
Alzheimer["Alzheimer"]
RELA["RELA"]
CCND1["CCND1"]
RHEB["RHEB"]
SPI1["SPI1"]
MIRNAS["MIRNAS"]
HNF4A["HNF4A"]
AXIN1["AXIN1"]
HSP70["HSP70"]
TXNIP["TXNIP"]
SOCS3["SOCS3"]
MICRORNAS["MICRORNAS"]
AMYLOID["AMYLOID"]
YWHAZ["YWHAZ"]
MYC["MYC"]
ALZHEIMER["ALZHEIMER"]
MYH9["MYH9"]
STAT3["STAT3"]
TBP <-->|"interacts"| Als
TBP -->|"expressed in"| Ms
TBP -->|"regulates"| Alzheimer
TBP -->|"activates"| RELA
TBP -->|"activates"| CCND1
TBP -->|"activates"| RHEB
TBP -->|"activates"| SPI1
TBP -->|"activates"| MIRNAS
TBP -->|"activates"| HNF4A
TBP -->|"activates"| AXIN1
HSP70 -->|"expressed in"| TBP
TXNIP -->|"activates"| TBP
SOCS3 -->|"activates"| TBP
MICRORNAS -->|"regulates"| TBP
AMYLOID -->|"regulates"| TBP
YWHAZ -->|"activates"| TBP
MYC -->|"activates"| TBP
ALZHEIMER -->|"regulates"| TBP
MYH9 -->|"activates"| TBP
STAT3 -->|"activates"| TBP
style TBP fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| Als | interacts_with | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| RELA | activates | gene | 0.60 |
| RHEB | activates | gene | 0.60 |
| SPI1 | activates | gene | 0.60 |
| HNF4A | activates | gene | 0.60 |
| AXIN1 | activates | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| YWHAZ | activates | gene | 0.60 |
| TXNIP | activates | gene | 0.60 |
| EGR1 | activates | gene | 0.60 |
| STAT3 | activates | gene | 0.60 |
| CCND1 | activates | gene | 0.60 |
| MIRNAS | activates | gene | 0.60 |
| Amyloid | regulates | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| AMYLOID | regulates | gene | 0.60 |
| MYH9 | activates | gene | 0.60 |
| MIR-155 | activates | gene | 0.60 |
| MICRORNAS | regulates | gene | 0.60 |
| Hippocampus | expressed_in | brain_region | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HSP70 | expressed_in | gene | 0.60 |
| TXNIP | activates | gene | 0.60 |
| SOCS3 | activates | gene | 0.60 |
| YWHAZ | activates | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| STAT3 | activates | gene | 0.60 |
| EGR1 | activates | gene | 0.60 |
| AXIN1 | activates | gene | 0.60 |
| RHEB | activates | gene | 0.60 |
| HNF4A | activates | gene | 0.60 |
| RELA | activates | gene | 0.60 |
| SPI1 | activates | gene | 0.60 |
| CCNF | implicated_in | gene | 0.60 |
| CTSF | implicated_in | gene | 0.60 |
| DNAJC7 | implicated_in | gene | 0.60 |
| GLT8D1 | implicated_in | gene | 0.60 |
| KIF5A | implicated_in | gene | 0.60 |
| MFSD8 | implicated_in | gene | 0.60 |
| NEK1 | implicated_in | gene | 0.60 |
| TBK1 | implicated_in | gene | 0.60 |
| MYO1C | activates | gene | 0.60 |
| MICRORNAS | regulates | gene | 0.60 |
| AMYLOID | regulates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| MYH9 | activates | gene | 0.60 |
| HUB GENES | regulates | gene | 0.60 |
| MIRNAS | activates | gene | 0.60 |
| MIR-155 | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| CCND1 | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||