gene

TBP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

56Connections
0Hypotheses
0Analyses
24Outgoing
32Incoming

Summary

TBP - TATA-Box Binding Protein

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🧬 Gene Info
Gene SymbolTBP
Full NameTATA-Box Binding Protein
Chromosome6q27
Protein TypeTranscription Factor
Functionis a general transcription factor essential for RNA polymerase II-mediated transcription initiation.
Amino Acids339 aa
Exons8
PathwaysAmyloid
UniProt IDP20226
NCBI Gene ID6908
Ensembl IDENSG00000112592
OMIM600075
GeneCardsTBP
Human Protein AtlasTBP
Chr Location6q27
Associated Diseasesneurodegeneration
InteractionsRELA, RHEB, SPI1, HNF4A, AXIN1, MYC
KG Connections56 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: TBP — AlphaFold P20226 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

TBP - TATA-Box Binding Protein

gene · 1363 words

Machado-Joseph Disease (Spinocerebellar Ataxia Type 3)

disease · 4154 words

Huntington Disease-Like Syndromes (HDL)

disease · 3141 words

medium-spiny-neurons-huntington-disease

cell_type · 3029 words

setd1a

gene · 2794 words

ATXN9 - Ataxin-9

gene · 2735 words

Pathway Diagram

graph TD
    TBP["TBP"]
    Als["Als"]
    Ms["Ms"]
    Alzheimer["Alzheimer"]
    RELA["RELA"]
    CCND1["CCND1"]
    RHEB["RHEB"]
    SPI1["SPI1"]
    MIRNAS["MIRNAS"]
    HNF4A["HNF4A"]
    AXIN1["AXIN1"]
    HSP70["HSP70"]
    TXNIP["TXNIP"]
    SOCS3["SOCS3"]
    MICRORNAS["MICRORNAS"]
    AMYLOID["AMYLOID"]
    YWHAZ["YWHAZ"]
    MYC["MYC"]
    ALZHEIMER["ALZHEIMER"]
    MYH9["MYH9"]
    STAT3["STAT3"]
    TBP <-->|"interacts"| Als
    TBP -->|"expressed in"| Ms
    TBP -->|"regulates"| Alzheimer
    TBP -->|"activates"| RELA
    TBP -->|"activates"| CCND1
    TBP -->|"activates"| RHEB
    TBP -->|"activates"| SPI1
    TBP -->|"activates"| MIRNAS
    TBP -->|"activates"| HNF4A
    TBP -->|"activates"| AXIN1
    HSP70 -->|"expressed in"| TBP
    TXNIP -->|"activates"| TBP
    SOCS3 -->|"activates"| TBP
    MICRORNAS -->|"regulates"| TBP
    AMYLOID -->|"regulates"| TBP
    YWHAZ -->|"activates"| TBP
    MYC -->|"activates"| TBP
    ALZHEIMER -->|"regulates"| TBP
    MYH9 -->|"activates"| TBP
    STAT3 -->|"activates"| TBP
    style TBP fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (24)

TargetRelationTypeStr
Alsinteracts_withdisease0.65
Msexpressed_indisease0.65
Alzheimerregulatesdisease0.65
RELAactivatesgene0.60
RHEBactivatesgene0.60

Incoming (32)

SourceRelationTypeStr
HSP70expressed_ingene0.60
TXNIPactivatesgene0.60
SOCS3activatesgene0.60
YWHAZactivatesgene0.60
MYCactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found