Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RIM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | RIM2 |
| Function | is a critical regulator of synaptic vesicle trafficking and neurotransmitter release in the central nervous system. |
| Subcellular Localization | to presynaptic active zones where it organizes the synaptic vesicle release mach |
| Molecular Weight | 200 kDa |
| Ensembl ID | ENSG00000156413 |
| GeneCards | RIM2 |
| Human Protein Atlas | RIM2 |
| Synaptic vesicle priming | Recruits vesicles to the active zone |
| Calcium channel coupling | Tethers voltage-gated calcium channels to vesicles |
| Neurotransmitter release | Facilitates synchronous and asynchronous release |
| Short-term plasticity | Regulates facilitation and depression |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RIM2["RIM2"]
neurodegeneration["neurodegeneration"]
RIM2 -->|"implicated_in"| neurodegeneration
style RIM2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-07 | 0 hypotheses
neurodegeneration | 2026-04-06 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity