protein

RIM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RIM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

5Hypotheses

3Analyses

0Outgoing

0Incoming

1Experiments

3Debates

Summary

Page for RIM2 Protein

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🔬 Protein Info

Gene Symbol	RIM2
Function	is a critical regulator of synaptic vesicle trafficking and neurotransmitter release in the central nervous system.
Subcellular Localization	to presynaptic active zones where it organizes the synaptic vesicle release mach
Molecular Weight	200 kDa
Ensembl ID	ENSG00000156413
GeneCards	RIM2
Human Protein Atlas	RIM2
Synaptic vesicle priming	Recruits vesicles to the active zone
Calcium channel coupling	Tethers voltage-gated calcium channels to vesicles
Neurotransmitter release	Facilitates synchronous and asynchronous release
Short-term plasticity	Regulates facilitation and depression
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RIM2["RIM2"]
    neurodegeneration["neurodegeneration"]
    RIM2 -->|"implicated_in"| neurodegeneration
    style RIM2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TRIM21 as a 'Phase Separation Thermostat' via Catalytic Reve	0.700	neurodegeneration	How does TRIM21-mediated K63 ubiquitinat
ALS-Associated G3BP1/2 Mutations Disrupt TRIM21 Binding Inte	0.585	neurodegeneration	How do pathological stress granules in n
TRIM21-Mediated Ubiquitination Creates Peripheral Epitope Gr	0.548	neurodegeneration	What determines the spatial organization
Hyperphosphorylated TDP-43 Traps TRIM21 Into Inactive Comple	0.487	neurodegeneration	How do pathological stress granules in n
Casein Kinase 2 (CK2)-Mediated Hyperphosphorylation of G3BP1	0.440	neurodegeneration	How do pathological stress granules in n

Mentioning Analyses (3)

Scientific analyses that reference this entity

What determines the spatial organization of autophagy receptors at stress granul

neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.633

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.730

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.717

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
TRIM21 E3 ubiquitin ligase screen for stress granule regulation	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

The study shows TRIM21 and autophagy receptors can eliminate both physiological

closed · Rounds: 4 · Score: 0.75 · 2026-04-22

The study shows that G3BP1 ubiquitination inhibits LLPS in vitro, but the molecu

closed · Rounds: 4 · Score: 0.79 · 2026-04-21

SQSTM1 and CALCOCO2 specifically localize to SG periphery rather than throughout

closed · Rounds: 4 · Score: 0.69 · 2026-04-21

Related Research

Hypotheses and analyses mentioning RIM2 in their description or question text

No additional research found