gene 3,093 words KG: TRIM2
Contents

TRIM2 Gene (Tripartite Motif Containing 2)

🧬 Gene Info
Gene SymbolTRIM2
Chromosome4q31.3
Protein TypeLigase
Functionencodes a neuron-specific E3 ubiquitin ligase that plays critical roles in protein quality control, axonal maintenance, cytoskeletal dynamics, and cellular defense mechanisms.
Molecular Weight85 kDa
Amino Acids741 aa
UniProt IDQ9C0B1
NCBI Gene ID23321
Ensembl IDENSG00000109654
OMIM614434
GeneCardsTRIM2
Human Protein AtlasTRIM2
RefSeqNM_001301138
Neurofilament Light (NEFL)K48-linked
Myosin IIA (MYH9)K63-linked
Associated DiseasesALS
InteractionsNCL
KG Connections41 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Autophagosome Maturation Checkpoint Control
Score: 0.49
VCP-Mediated Autophagy Enhancement
Score: 0.41
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (6)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (15)

Optineurin
protein · KG edge: co_discussed
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: co_discussed
Dementia Australia
institution · KG edge: co_discussed
STING Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

TRIM2 co_discussed TRIM28
TRIM2 co_discussed UBIQUITIN
TRIM2 co_discussed G3BP1
TRIM2 co_discussed ACTB
TRIM2 co_discussed BECN1
TRIM2 co_discussed C9ORF72
TRIM2 co_discussed SMCR8
TRIM2 co_discussed CALCOCO2
TRIM2 co_discussed NDP52
TRIM2 co_discussed FUS