gene 2,027 words KG: TRIM25
Contents

TRIM25 Gene (Tripartite Motif Containing 25)

🧬 Gene Info
Gene SymbolTRIM25
Full NameTRIM25 (Tripartite Motif Containing 25)
Chromosome17q11.2
Protein TypeGene
Functionencodes an E3 ubiquitin ligase that plays critical roles in multiple cellular processes including innate immunity, mitochondrial dynamics, and protein quality control.
Subcellular Localizationand activity
Molecular Weight55 kDa
Amino Acids504 aa
Exons6
PathwaysMitophagy
UniProt IDQ9C0B1
NCBI Gene ID11067
Ensembl IDENSG00000120937
OMIM606112
GeneCardsTRIM25
Human Protein AtlasTRIM25
Associated Diseasescerebral ischemia-reperfusion injury
InteractionsAND, APOE, ATAD3A, AUTOPHAGY, BNIP3, BRCA2
KG Connections110 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (19)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Autophagosome Maturation Checkpoint Control
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Mitochondria
entity · KG edge: regulates
BNIP3 Gene
gene · KG edge: activates
BRCA2 Gene
gene · KG edge: activates
DRP1 Gene - Dynamin 1-Like Protein
gene · KG edge: degrades
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: activates

Knowledge Graph (12 edges)

TRIM25 activates PINK1/Parkin signaling pathway
TRIM25 causes cerebral ischemia-reperfusion injury
PARKIN activates TRIM25
P62 associated_with TRIM25
TRIM25 activates PINK1
LC3 activates TRIM25
P62 activates TRIM25
TRIM25 activates BRCA2
MECOM activates TRIM25
TRIM25 activates EGFR

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