gene 2,027 words KG: TRIM25 2026-03-26
kind:genesection:genestopic:parkinsonstopic:alzheimers
Contents

TRIM25 Gene (Tripartite Motif Containing 25)

🧬 Gene Info
Gene SymbolTRIM25
Full NameTRIM25 (Tripartite Motif Containing 25)
Chromosome17q11.2
Protein TypeGene
Functionencodes an E3 ubiquitin ligase that plays critical roles in multiple cellular processes including innate immunity, mitochondrial dynamics, and protein quality control.
Subcellular Localizationand activity
Molecular Weight55 kDa
Amino Acids504 aa
Exons6
PathwaysMitophagy
UniProt IDQ9C0B1
NCBI Gene ID11067
Ensembl IDENSG00000120937
OMIM606112
GeneCardsTRIM25
Human Protein AtlasTRIM25
Associated Diseasescerebral ischemia-reperfusion injury
InteractionsPINK1, BRCA2, EGFR, HOXA10-HOXA9, BNIP3, NFKBIA
KG Connections112 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (19)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: activates
ER Stress and Unfolded Protein Response in Corticobasal
mechanism · KG edge: activates
MECOM Gene
gene · KG edge: activates
MAP1LC3A Gene
gene · KG edge: activates
ISG15 — Interferon-Stimulated Gene 15
gene · KG edge: regulates

Knowledge Graph (12 edges)

TRIM25 associated_with ATAD3A
TRIM25 activates PINK1
TRIM25 activates BRCA2
TRIM25 activates EGFR
TRIM25 activates HOXA10-HOXA9
TRIM25 expressed_in NRF2
TRIM25 expressed_in KEAP1
TRIM25 mediates NFKBIA
TRIM25 degrades NFKBIA
TRIM25 regulates BNIP3