gene 1,425 words KG: TRIM24
Contents

TRIM24 — Tripartite Motif Containing 24

🧬 Gene Info
Gene SymbolTRIM24
Full NameTripartite Motif Containing 24
Chromosome7q33
Protein TypeLigase
Functionis a transcriptional coactivator and E3 ubiquitin ligase that plays key roles in gene regulation, DNA damage response, and cellular stress responses [1](https://pubmed.
Primary Expressionvarious cancers:
Amino Acids008 aa
Exons17
UniProt ID[Q9Y2X9](https://www.uniprot.org/uniprot/Q9Y2X9)
Ensembl IDENSG00000108344
OMIM603546
GeneCardsTRIM24
Human Protein AtlasTRIM24
RING fingerA C3HC4 RING domain with E3 ubiquitin ligase activity
B boxesTwo B-box domains involved in protein-protein interactions
Associated DiseasesAging, Als, Alzheimer, Heart Failure, Ms
InteractionsCGAS, DNA, DSDNA, GENES, P53, STING
KG Connections46 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (18)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
RNA Granule Nucleation Site Modulation
Score: 0.66

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Cardiac MIBG Scan for Parkinsonism
diagnostic · KG edge: regulates
Progressive Supranuclear Palsy (PSP)
disease · KG edge: associated_with
Astrocytes
entity · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: inhibits
Genes
index · KG edge: activates

Knowledge Graph (12 edges)

NFKB1 therapeutic_target TRIM24
TRIM24 therapeutic_target TDP1
TRIM24 therapeutic_target MAPK1
TRIM24 therapeutic_target CTSD
TRIM24 therapeutic_target HIF1A
DUSP10 associated_with TRIM24
MAP1S associated_with TRIM24
PSP associated_with TRIM24
SP1 associated_with TRIM24
APOE associated_with TRIM24

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