gene 1,425 words KG: TRIM24 2026-03-27
kind:genesection:genesstate:published
Contents

TRIM24 — Tripartite Motif Containing 24

🧬 Gene Info
Gene SymbolTRIM24
Full NameTripartite Motif Containing 24
Chromosome7q33
Protein TypeLigase
Functionis a transcriptional coactivator and E3 ubiquitin ligase that plays key roles in gene regulation, DNA damage response, and cellular stress responses [1](https://pubmed.
Primary Expressionvarious cancers:
Amino Acids008 aa
Exons17
UniProt ID[Q9Y2X9](https://www.uniprot.org/uniprot/Q9Y2X9)
Ensembl IDENSG00000108344
OMIM603546
GeneCardsTRIM24
Human Protein AtlasTRIM24
RING fingerA C3HC4 RING domain with E3 ubiquitin ligase activity
B boxesTwo B-box domains involved in protein-protein interactions
Associated DiseasesAging, Als, Alzheimer, Heart Failure, Ms
InteractionsTREX1, CGAS, STING, UBIQUITIN, DNA, GENES
KG Connections46 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (18)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.41
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.40

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Tau Consortium
organization · KG edge: associated_with
erk-mapk-signaling-neurodegeneration
mechanism · KG edge: therapeutic_target
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: implicated_in
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with

Knowledge Graph (12 edges)

TRIM24 therapeutic_target TDP1
TRIM24 therapeutic_target MAPK1
TRIM24 therapeutic_target CTSD
TRIM24 therapeutic_target HIF1A
TRIM24 associated_with STX6
TRIM24 associated_with MAPT
TRIM24 activates TREX1
TRIM24 inhibits CGAS
TRIM24 inhibits STING
TRIM24 activates UBIQUITIN