protein 1,263 words KG: TRIM28 2026-03-26
kind:proteinsection:proteinsstate:published
Contents

TRIM28 (KAP1) Protein

🔬 Protein Info
Gene SymbolTRIM28
Full NameTranscriptional Intermediary Factor 1 Beta (TIF1β)
AliasesTranscriptional Intermediary Factor 1 Beta
Protein FamilyTRIM family, transcriptional co-repressors
FunctionUpon KRAB-ZFP binding to DNA, TRIM28 is recruited through interaction with the KRAB domain.
Subcellular LocalizationNucleus (predominantly), also in cytoplasm
Molecular Weight110 kDa (835 amino acids)
Amino Acids835 aa
PathwaysFerroptosis
UniProt IDQ13263
GeneCardsTRIM28
Human Protein AtlasTRIM28
Protein NameTranscriptional Intermediary Factor 1 Beta (TIF1β)
GeneTRIM28
PDB Structures2JSS, 2L3V, 4DT3, 5YJC
Associated Diseasesneurodegeneration
InteractionsSLC7A11, STAT6, HDAC5, UBIQUITIN, FERROPTOSIS, CANCER
KG Connections28 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Cryptic Exon Silencing Restoration
Score: 0.46
Cross-Seeding Prevention Strategy
Score: 0.45

Related Analyses (7)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Ubiquitin
protein · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: interacts_with
TRIM2 Gene (Tripartite Motif Containing 2)
gene · KG edge: co_discussed
STING Gene
gene · KG edge: co_discussed
STAT6 — Signal Transducer and Activator of Transcriptio
gene · KG edge: activates

Knowledge Graph (12 edges)

TRIM28 inhibits HDAC5
TRIM28 activates SLC7A11
TRIM28 activates STAT6
TRIM28 activates HDAC5
TRIM28 interacts_with UBIQUITIN
TRIM28 activates Tumor
TRIM28 activates Carcinoma
TRIM28 activates Cancer
TRIM28 activates Ferroptosis
TRIM28 activates FERROPTOSIS