pathway

Dna Damage Response

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Dna Damage Response: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

246Connections

0Hypotheses

0Analyses

8Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	Dna Damage Response
Summary	Page for DNA Damage Response Impairment Pathway
Key Genes/Proteins	Protein Arginine Methyltransferases, AQP1, SETX, NUPR2, ATM, DNA
Related Diseases	Alzheimer'S Disease

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DNA["DNA"] -->|"associated"| Dna_Damage_Response["Dna Damage Response"]
    style DNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ATM["ATM"] -.->|"inhibits"| Dna_Damage_Response["Dna Damage Response"]
    style ATM fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    P53["P53"] -.->|"inhibits"| Dna_Damage_Response["Dna Damage Response"]
    style P53 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AND["AND"] -.->|"inhibits"| Dna_Damage_Response["Dna Damage Response"]
    style AND fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| Dna_Damage_Response["Dna Damage Response"]
    style APOPTOSIS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style Dna_Damage_Response fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (51)

Target	Relation	Type	Str
Alzheimer'S Disease	associated_with	disease	0.85
Reactive Oxygen Species	activates	process	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
HOMOLOGOUS RECOMBINATION	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
PD-L1	activates	concept	0.50
GENE EXPRESSION	interacts_with	concept	0.50
Proteins	interacts_with	protein	0.50

Incoming (195)

Source	Relation	Type	Str
Protein Arginine Methyltransferases	regulates	protein	0.90
AQP1	modulates	gene	0.85
AQP1	regulates	gene	0.85
Autophagy	interacts_with	process	0.85
SETX	involved_in	protein	0.85
Oligodendrocytes	expressed_in	cell_type	0.85
NUPR2	involved_in	gene	0.75
ATM	involved_in	gene	0.70
DNA	associated_with	gene	0.60
ATM	inhibits	gene	0.60
P53	inhibits	gene	0.60
AND	inhibits	gene	0.60
APOPTOSIS	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
AND	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
ATM	regulates	gene	0.60
AGING	regulates	gene	0.60
ROS	regulates	gene	0.60
CANCER	regulates	gene	0.60
DNA	regulates	gene	0.60
PTEN	regulates	gene	0.60
RPA2	regulates	gene	0.60
NAD	regulates	gene	0.60
SIRT1	regulates	gene	0.60
CGAS	activates	gene	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
STING	activates	gene	0.60
CANCER	biomarker_for	gene	0.60
CGAS-STING	activates	gene	0.60
DNA	activates	gene	0.60
ATM	activates	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
ACETYL-COA	activates	gene	0.60
AGING	activates	gene	0.60
BNIP3	activates	gene	0.60
P16	activates	gene	0.60
SETX	regulates	gene	0.60
ALS4	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
CYTOKINES	activates	gene	0.60
NF-ΚB	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
ATM	therapeutic_target	gene	0.60
ATR	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Dna Damage Response

Understanding Entity Pages

Wiki Pages (21)