protein

RPN2PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPN2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Debates

Summary

The endoplasmic reticulum is a specialized organelle responsible for protein synthesis, folding, and quality control.

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🔬 Protein Info

Gene Symbol	RPN2PROTEIN
Protein Type	Transferase
Function	is an essential component of the oligosacchryltransferase (OST) complex located in the endoplasmic reticulum (ER) membrane.
Subcellular Localization	</strong></td><td>Endoplasmic reticulum membrane</td></tr>
Molecular Weight	69 kDa
GeneCards	RPN2PROTEIN
Human Protein Atlas	RPN2PROTEIN
N-terminal luminal domain	Catalytic OST subunit interaction
Transmembrane domain	Single-pass membrane anchor
C-terminal domain	STT3A/STT3B binding
OST core	RPN1, RPN2, STT3A, STT3B, DAD1, OTF
Accessory subunits	MagT1, TUSC3, KCP2
Ribosome interaction	Direct binding to Sec61 translocon
Calnexin/calreticulin cycle	Glycan-dependent folding
ER-associated degradation (ERAD)	Misfolded protein clearance
Associated Diseases	cancer
Interactions	ADRA2A, BCL-2, CANCER, CTSD, INFLAMMATION, MAOA
KG Connections	22 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ribophorin II Protein

protein · 744 words

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Pathway Diagram

graph TD
    RPN2PROTEIN["RPN2PROTEIN"]
    neurodegeneration["neurodegeneration"]
    RPN2PROTEIN -->|"implicated_in"| neurodegeneration
    style RPN2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning RPN2PROTEIN in their description or question text

No additional research found