Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RETINAL GANGLION CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | RETINAL GANGLION CELLS |
Knowledge base pages for this entity
graph TD
RETINAL_GANGLION_CELLS["RETINAL GANGLION CELLS"]
RETINAL_GANGLION_CELLS -.biomarker for.-> Multiple_Sclerosis["Multiple Sclerosis"]
Mitochondrial_Dysfunction["Mitochondrial Dysfunction"] -->|"involved_in"| RETINAL_GANGLION_CELLS
Perivascular_Niche["Perivascular Niche"] -.protects against.-> RETINAL_GANGLION_CELLS
SIRT6["SIRT6"] -->|"expressed in"| RETINAL_GANGLION_CELLS
Aging_Signature["Aging Signature"] -->|"expressed in"| RETINAL_GANGLION_CELLS
AHR["AHR"] -.protects against.-> RETINAL_GANGLION_CELLS
Experimental_Autoimmune_Enceph["Experimental Autoimmune Encephalomyelitis"] -->|"causes"| RETINAL_GANGLION_CELLS
Aged_Cell_Transcriptional_Sign["Aged Cell Transcriptional Signature"] -.biomarker for.-> RETINAL_GANGLION_CELLS
TNF["TNF"] -->|"expressed in"| RETINAL_GANGLION_CELLS| Target | Relation | Type | Str |
|---|---|---|---|
| Aging Signature | associated_with | biomarker | 0.85 |
| Multiple Sclerosis | biomarker_for | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Mitochondrial Dysfunction | associated_with | process | 0.98 |
| Diabetic Retinopathy | causes | disease | 0.95 |
| BDNF | protects_against | protein | 0.92 |
| Perivascular Niche | protects_against | process | 0.90 |
| SIRT6 | expressed_in | gene | 0.90 |
| SIRT6 | protects_against | protein | 0.90 |
| Mitochondrial Dysfunction | involved_in | process | 0.90 |
| Aging Signature | expressed_in | biomarker | 0.85 |
| Senescent Features | associated_with | phenotype | 0.85 |
| Experimental Autoimmune Encephalomyelitis | causes | disease | 0.80 |
| TNF-α | associated_with | protein | 0.80 |
| Aged Cell Transcriptional Signature | biomarker_for | biomarker | 0.75 |
| Nuclear Envelope Alterations | associated_with | phenotype | 0.75 |
| TNF | expressed_in | protein | 0.70 |
| A1 astrocytes | causes | cell_type | 0.70 |
| glaucoma | causes | disease | 0.70 |
| RIPK1 | regulates | protein | 0.70 |
| OPTN | expressed_in | gene | 0.70 |
| MTOR | expressed_in | gene | 0.70 |
| oxidative stress | causes | process | 0.70 |
| microglia | activates | cell_type | 0.70 |
| microglia | causes | cell_type | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||