disease

glaucoma

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about glaucoma: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1047Connections
0Hypotheses
0Analyses
1Outgoing
24Incoming

Summary

glaucoma is a disease characterized by neurodegeneration research. Key relationships include: associated with, treats, protects against. Connected to 13 entities in the SciDEX knowledge graph.

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Disease Info
Prevalence~80 million people worldwide
Associated GenesTNF, RIPK1, OPTN, NPY, Piezo1, RIP3
Therapeutic AgentsRIPK1 inhibition, indoleacetic acid
KG Connections25 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

therapeutic · 5600 words

Neuroprotection Strategies in Neurodegeneration

therapeutic · 4093 words

Gene-Mechanism-Therapy Causal Chains

mechanism · 4075 words

KarXT for Alzheimer's Disease Cognitive Impairment - MINDSET 2 (NCT06976203)

clinical · 3985 words

Pathway Diagram

graph TD
    GLAUCOMA["GLAUCOMA"]
    GLAUCOMA -->|"causes"| retinal_ganglion_cells["retinal ganglion cells"]
    GLAUCOMA -->|"target for"| Complement["Complement"]
    GLAUCOMA -->|"target for"| Inflammasome["Inflammasome"]
    GLAUCOMA -->|"activates"| Senescence["Senescence"]
    GLAUCOMA -->|"inhibits"| Neuroinflammatory["Neuroinflammatory"]
    GLAUCOMA -->|"contributes to"| Apoptosis["Apoptosis"]
    AHR_RAGE_Pathway["AHR/RAGE Pathway"] -->|"involved_in"| GLAUCOMA
    Tryptophan_Metabolites["Tryptophan Metabolites"] -.protects against.-> GLAUCOMA
    APOE3["APOE3"] -->|"contributes to"| GLAUCOMA
    APOE4["APOE4"] -.protects against.-> GLAUCOMA
    RIPK1["RIPK1"] -->|"causes"| GLAUCOMA
    RIPK1_inhibition["RIPK1 inhibition"] -->|"treats"| GLAUCOMA
    NRF2["NRF2"] -->|"regulates"| GLAUCOMA
    p38["p38"] -.biomarker for.-> GLAUCOMA
    NADPH["NADPH"] -->|"treats"| GLAUCOMA
    NAC["NAC"] -->|"treats"| GLAUCOMA

Outgoing (494)

TargetRelationTypeStr
retinal ganglion cellscausescell_type0.70

Incoming (553)

SourceRelationTypeStr
OPTNrisk_factor_forgene0.95
family historyrisk_factor_forphenotype0.90
inflammatory factor releasepromotesprocess0.85
AhRprotects_againstprotein0.82
MTORtherapeutic_targetgene0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found