Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about glaucoma: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
glaucoma is a disease characterized by neurodegeneration research. Key relationships include: associated with, treats, protects against. Connected to 13 entities in the SciDEX knowledge graph.
| Prevalence | ~80 million people worldwide |
| Associated Genes | TNF, RIPK1, OPTN, NPY, Piezo1, RIP3 |
| Therapeutic Agents | RIPK1 inhibition, indoleacetic acid |
| KG Connections | 25 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
GLAUCOMA["GLAUCOMA"]
GLAUCOMA -->|"causes"| retinal_ganglion_cells["retinal ganglion cells"]
GLAUCOMA -->|"target for"| Complement["Complement"]
GLAUCOMA -->|"target for"| Inflammasome["Inflammasome"]
GLAUCOMA -->|"activates"| Senescence["Senescence"]
GLAUCOMA -->|"inhibits"| Neuroinflammatory["Neuroinflammatory"]
GLAUCOMA -->|"contributes to"| Apoptosis["Apoptosis"]
AHR_RAGE_Pathway["AHR/RAGE Pathway"] -->|"involved_in"| GLAUCOMA
Tryptophan_Metabolites["Tryptophan Metabolites"] -.protects against.-> GLAUCOMA
APOE3["APOE3"] -->|"contributes to"| GLAUCOMA
APOE4["APOE4"] -.protects against.-> GLAUCOMA
RIPK1["RIPK1"] -->|"causes"| GLAUCOMA
RIPK1_inhibition["RIPK1 inhibition"] -->|"treats"| GLAUCOMA
NRF2["NRF2"] -->|"regulates"| GLAUCOMA
p38["p38"] -.biomarker for.-> GLAUCOMA
NADPH["NADPH"] -->|"treats"| GLAUCOMA
NAC["NAC"] -->|"treats"| GLAUCOMA| Target | Relation | Type | Str |
|---|---|---|---|
| retinal ganglion cells | causes | cell_type | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| OPTN | risk_factor_for | gene | 0.95 |
| family history | risk_factor_for | phenotype | 0.90 |
| inflammatory factor release | promotes | process | 0.85 |
| AhR | protects_against | protein | 0.82 |
| MTOR | therapeutic_target | gene | 0.80 |
| LPS-TLR4 pathway | upstream_of | pathway | 0.80 |
| dysbiosis | promotes | process | 0.80 |
| OPTN | genetic_marker_for | gene | 0.80 |
| vascular dysregulation | risk_factor_for | process | 0.80 |
| NPY | implicated_in | gene | 0.80 |
| APOE3 | contributes_to | protein | 0.80 |
| depression | risk_factor_for | phenotype | 0.75 |
| APOE4 | protects_against | protein | 0.70 |
| TNF | associated_with | protein | 0.70 |
| RIPK1 | causes | protein | 0.70 |
| RIPK1 inhibition | treats | drug | 0.70 |
| OPTN | associated_with | gene | 0.70 |
| NRF2 | regulates | protein | 0.70 |
| indoleacetic acid | treats | drug | 0.70 |
| gut dysbiosis | associated_with | process | 0.70 |
| indoleacetic acid | protects_against | drug | 0.70 |
| Piezo1 | associated_with | gene | 0.70 |
| RIP3 | associated_with | protein | 0.70 |
| aging | associated_with | phenotype | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||