gene 642 words KG: SAP97 2026-03-24
kind:genesection:genesstate:published
Contents

SAP97 - Synapse-Associated Protein 97

🧬 Gene Info
Gene SymbolSAP97
Full NameSynapse-Associated Protein 97
AliasesPage for SAP97
Chromosome3q29
Protein TypeKinase
FunctionSAP97 (also known as DLG1) is a member of the membrane-associated guanylate kinase (MAGUK) family of scaffold proteins.
Subcellular Localizationand functional properties, with implications for synaptic function and neuronal health
PathwaysPI3K, mTOR, mtor, MTOR
Ensembl IDENSG00000150048
GeneCardsSAP97
Human Protein AtlasSAP97
PSD-95Related MAGUK scaffold protein with overlapping synaptic functions
GKAP/SAPAPBinding partner mediating SAP97 interactions with PSD scaffolds
Stargazin/TARPAMPA receptor auxiliary subunit regulated by SAP97
Postsynaptic DensitySynaptic protein complex organized by SAP97
Associated Diseasesschizophrenia
InteractionsGluA1, MAP1B, PSD-95
KG Connections10 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.61
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.56
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (10)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (3)

CASK — Calcium/Calmodulin-Dependent Serine Protein Kina
gene · KG edge: binds
PSD-95 (Postsynaptic Density Protein 95)
entity · KG edge: interacts_with
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (10 edges)

SAP97 binds NR2A
SAP97 associated_with schizophrenia
SAP97 interacts_with GluA1
SAP97 contributes_to neuropathic pain
CASK binds SAP97
CaMKII phosphorylates SAP97
CaMKII regulates SAP97
MAP1B activates SAP97
PSD-95 interacts_with SAP97
PSD-95 activates SAP97