disease

schizophrenia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about schizophrenia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1330Connections

0Hypotheses

0Analyses

33Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	SEZ6, SAP97, TCF4, AADC, CACNA1G, FCGRT, DRD2, SNAP25
Therapeutic Agents	ketamine
KG Connections	169 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SCHIZOPHRENIA["SCHIZOPHRENIA"]
    SCHIZOPHRENIA -->|"regulates"| Synaptic_Plasticity["Synaptic Plasticity"]
    SCHIZOPHRENIA -->|"inhibits"| Complement["Complement"]
    SCHIZOPHRENIA -->|"target for"| Mtor["Mtor"]
    SCHIZOPHRENIA -->|"target for"| Autophagy["Autophagy"]
    SCHIZOPHRENIA -->|"activates"| Neurogenesis["Neurogenesis"]
    SCHIZOPHRENIA -->|"target for"| Epigenetic["Epigenetic"]
    JUN["JUN"] -->|"regulates"| SCHIZOPHRENIA
    DAB1["DAB1"] -->|"regulates"| SCHIZOPHRENIA
    FYN["FYN"] -->|"regulates"| SCHIZOPHRENIA
    SRC["SRC"] -->|"regulates"| SCHIZOPHRENIA
    CNO["CNO"] -->|"regulates"| SCHIZOPHRENIA
    PLA2G6["PLA2G6"] -->|"activates"| SCHIZOPHRENIA
    PLA2G4A["PLA2G4A"] -->|"activates"| SCHIZOPHRENIA

Outgoing (350)

Target	Relation	Type	Str
interneurons	affects	cell_type	0.90
cortex	affects	brain_region	0.90
neurons	affects	cell_type	0.90
serotonin	disrupts	neurotransmitter	0.80
NMDA receptor	involves	receptor	0.80
oxidative stress response	involves	pathway	0.80
striatum	affects	brain_region	0.70
thalamus	affects	brain_region	0.70
cerebellum	affects	brain_region	0.70
pyramidal neurons	affects	cell_type	0.70
nicotinic receptor	involves	receptor	0.70
dopamine receptor	involves	receptor	0.70
blood-brain barrier	affects	brain_region	0.70
synaptic plasticity	involves	pathway	0.70
prefrontal cortex	affects	brain_region	0.60
hypothalamus	affects	brain_region	0.60
amygdala	affects	brain_region	0.60
glutamate signaling	involves	pathway	0.60
temporal lobe	affects	brain_region	0.60
nucleus accumbens	affects	brain_region	0.60
subventricular zone	affects	brain_region	0.60
muscarinic receptor	involves	receptor	0.60
cerebral cortex	affects	brain_region	0.60
neuropeptide Y	disrupts	neurotransmitter	0.60
oxytocin	disrupts	neurotransmitter	0.60
ferroptosis	involves	pathway	0.60
microglia	affects	cell_type	0.60
endothelial cells	affects	cell_type	0.60
macrophages	affects	cell_type	0.60
ubiquitin-proteasome	involves	pathway	0.60
neural stem cells	affects	cell_type	0.60
GABAergic neurons	affects	cell_type	0.60
epigenetic regulation	involves	pathway	0.60

Incoming (980)

Source	Relation	Type	Str
dopamine signaling	implicated_in	pathway	0.95
REELIN	implicated_in	protein	0.80
PLA2G4A	affects	gene	0.80
CHRFAM7A	implicated_in	gene	0.80
Reelin Signaling Pathway	associated_with	pathway	0.80
BDNF	biomarker_for	protein	0.75
SEZ6	associated_with	protein	0.70
SAP97	associated_with	protein	0.70
TCF4	associated_with	gene	0.70
PVALB	regulates	gene	0.70
CHRNA7	associated_with	gene	0.70
DISC1	interacts_with	gene	0.70
DRD2	interacts_with	gene	0.70
GRN	associated_with	gene	0.70
FUS	associated_with	gene	0.70
DNA	biomarker_for	gene	0.70
AADC	implicated_in	gene	0.60
CACNA1G	associated_with	gene	0.60
FCGRT	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
SNAP25	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
VIPR2	associated_with	gene	0.60
PLA2G4A	associated_with	gene	0.60
PLA2G6	associated_with	gene	0.60
PLA2G4A	biomarker_for	gene	0.60
PLA2G4A	expressed_in	gene	0.60
C4B	expressed_in	gene	0.60
AADC	associated_with	gene	0.60
PVALB	expressed_in	gene	0.60
PVALB	associated_with	gene	0.60
PVALB	implicated_in	gene	0.60
GPR109A	treats	gene	0.60
HSPG2	treats	gene	0.60
CHRNA7	implicated_in	gene	0.60
CHRNA7	expressed_in	gene	0.60
CHRNA7	biomarker_for	gene	0.60
DRD2	implicated_in	gene	0.60
DRD2	treats	gene	0.60
HCRTR1	associated_with	gene	0.60
VEGFA	associated_with	gene	0.60
GBA	associated_with	gene	0.60
PLA2G4A	interacts_with	gene	0.60
PLA2G6	interacts_with	gene	0.60
C4A	interacts_with	gene	0.60
C4	interacts_with	gene	0.60
C4B	interacts_with	gene	0.60
RGS4	interacts_with	gene	0.60
GRM4	interacts_with	gene	0.60
GRM3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

schizophrenia

Understanding Entity Pages

Wiki Pages (20)

primary-progressive-aphasia

GRIA3 Gene

Frontotemporal Dementia (FTD)

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

TREM2 Mechanism Hub

CNTN5 — Contactin 5

CNTN4 — Contactin 4

Sulforaphane and Nrf2 Activation for Neuroprotection

substantia-nigra

dimethyl-fumarate-nrf2-ad-nct06850597

CNTN3 — Contactin 3

NPAS3 Gene

PEN2 Gene

KarXT for Alzheimer's Disease Cognitive Impairment - MINDSET 2 (NCT06976203)

Beta-Secretase (BACE1) Protein

Multiple Sclerosis (MS)

Metabolomic Alterations in PSP