gene

SLC6A14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC6A14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

6Outgoing

0Incoming

0Experiments

0Debates

Summary

Solute Carrier Family 6 Member 14 (Amino Acid Transporter) gene

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🧬 Gene Info

Gene Symbol	SLC6A14
Aliases	Amino Acid Transporter
Chromosome	9q32
Function	encodes a 12-transmembrane-domain protein of approximately 629 amino acids.
Primary Expression	epithelial tissues including intestine, lung, mammary gland, and brain
Amino Acids	629 aa
Pathways	Immune Response, Inflammasome, Mapk
GeneCards	SLC6A14
Human Protein Atlas	SLC6A14
N-terminal intracellular domain	Contains regulatory serine/threonine residues
Transmembrane core	Forms the broad substrate-binding pocket
Large extracellular loops	Contains glycosylation sites
C-terminal intracellular tail	Contains potential PDZ-binding motif
Associated Diseases	neurodegeneration
KG Connections	6 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC6A14 Gene

gene · 1237 words

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Pathway Diagram

flowchart TD
    SLC6A14(["SLC6A14"])
    Inflammation["Inflammation"]
    INFLAMMATION(["INFLAMMATION"])
    NLRP3(["NLRP3"])
    Mapk["Mapk"]
    Immune_Response["Immune Response"]
    Inflammasome["Inflammasome"]
    neurodegeneration["neurodegeneration"]

    SLC6A14 -->|"regulates"| Inflammation
    SLC6A14 -->|"regulates"| INFLAMMATION
    SLC6A14 -->|"regulates"| NLRP3
    SLC6A14 -->|"regulates"| Mapk
    SLC6A14 -->|"regulates"| Immune_Response
    SLC6A14 -->|"regulates"| Inflammasome
    SLC6A14 -->|"implicated in"| neurodegeneration

    style SLC6A14 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (6)

Target	Relation	Type	Str
Inflammation	regulates	disease	0.65
NLRP3	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
Mapk	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
Inflammasome	regulates	pathway	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC6A14 in their description or question text

No additional research found