Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Inflammasome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Inflammasome is a biological pathway involved in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Aging, Als. Connected to 778 entities in the SciDEX knowledge graph.
| Name | Inflammasome |
| Key Genes/Proteins | NLRP3, ASC, TNF |
| Related Diseases | Inflammation, Als, Neuroinflammation, Aging, Atherosclerosis |
| Linked Hypotheses | 7 hypotheses |
Knowledge base pages for this entity
graph TD
Inflammasome["Inflammasome"] -->|"interacts"| Complement["Complement"]
Inflammasome["Inflammasome"] -->|"interacts"| Blood_Brain_Barrier["Blood-Brain Barrier"]
Inflammasome["Inflammasome"] -->|"interacts"| Pyroptosis["Pyroptosis"]
Inflammasome["Inflammasome"] -->|"interacts"| Autophagy["Autophagy"]
Inflammasome["Inflammasome"] -->|"interacts"| Nf__b["Nf-Kappab"]
Inflammasome["Inflammasome"] -->|"interacts"| Mitophagy["Mitophagy"]
NLRP3["NLRP3"] -->|"activates"| Inflammasome["Inflammasome"]
C1Q["C1Q"] -->|"activates"| Inflammasome["Inflammasome"]
ACTB["ACTB"] -.->|"inhibits"| Inflammasome["Inflammasome"]
IL1B["IL1B"] -.->|"inhibits"| Inflammasome["Inflammasome"]
style Inflammasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Microglia | activates | cell_type | 0.95 |
| Glycolysis | upregulates | pathway | 0.95 |
| Oxidative Phosphorylation | downregulates | pathway | 0.95 |
| M1 Polarization | causes | phenotype | 0.95 |
| Neuroinflammation | activates | process | 0.95 |
| Microglial M1 Polarization | causes | phenotype | 0.95 |
| ALZHEIMER'S DISEASE | contributes_to | disease | 0.95 |
| PARKINSON'S DISEASE | contributes_to | disease | 0.95 |
| ALS | contributes_to | disease | 0.95 |
| Neurodegeneration | promotes | process | 0.95 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.95 |
| DEMENTIA | contributes_to | disease | 0.92 |
| Dopaminergic Neurodegeneration | mediates | process | 0.90 |
| Misfolded Protein Aggregation | associated_with | process | 0.90 |
| NEUROINFLAMMATION | mediates | process | 0.89 |
| Protein Aggregation | associated_with | process | 0.88 |
| Alzheimer Disease | associated_with | disease | 0.85 |
| Parkinson Disease | associated_with | disease | 0.85 |
| Oxidative Phosphorylation | inhibits | process | 0.85 |
| Complement | interacts_with | pathway | 0.55 |
| Blood-Brain Barrier | interacts_with | pathway | 0.55 |
| Pyroptosis | interacts_with | pathway | 0.55 |
| Autophagy | interacts_with | pathway | 0.55 |
| Nf-Κb | interacts_with | pathway | 0.55 |
| Mitophagy | interacts_with | pathway | 0.55 |
| Ferroptosis | interacts_with | pathway | 0.55 |
| Oxidative Stress | interacts_with | pathway | 0.55 |
| Mtor | interacts_with | pathway | 0.55 |
| Apoptosis | interacts_with | pathway | 0.55 |
| Epigenetic | interacts_with | pathway | 0.55 |
| Insulin Signaling | interacts_with | pathway | 0.55 |
| Er Stress | interacts_with | pathway | 0.55 |
| Unfolded Protein Response | interacts_with | pathway | 0.55 |
| Astrocyte | activates | cell_type | 0.50 |
| Neuron | inhibits | cell_type | 0.50 |
| Dopaminergic | inhibits | cell_type | 0.50 |
| Macrophage | associated_with | cell_type | 0.50 |
| Neuron | activates | cell_type | 0.50 |
| Dopaminergic | activates | cell_type | 0.50 |
| Macrophage | activates | cell_type | 0.50 |
| Macrophage | inhibits | cell_type | 0.50 |
| Monocyte | inhibits | cell_type | 0.50 |
| Epithelial | activates | cell_type | 0.50 |
| Stem Cell | therapeutic_target | cell_type | 0.50 |
| Neuron | therapeutic_target | cell_type | 0.50 |
| Dopaminergic | therapeutic_target | cell_type | 0.50 |
| Microglia | contributes_to | cell_type | 0.50 |
| Macrophage | causes | cell_type | 0.50 |
| Neutrophil | activates | cell_type | 0.50 |
| Endothelial | activates | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NLRP3 | activates | gene | 1.00 |
| NLRP3 | inhibits | gene | 1.00 |
| ASC | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Atherosclerosis | activates | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| PYROPTOSIS | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| IL-6 | inhibits | gene | 1.00 |
| NLRP3 | regulates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| UBIQUITIN | activates | gene | 1.00 |
| AIM2 | activates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| Infection | activates | disease | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| CANCER | activates | gene | 1.00 |
| PARKIN | activates | gene | 1.00 |
| IL-6 | activates | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| AMYLOID | activates | gene | 1.00 |
| TNF | inhibits | gene | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 | 0.601 | neurodegeneration | What are the mechanisms by which gut mic |
| Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S | 0.599 | neurodegeneration | What are the mechanisms by which gut mic |
| Microbial Inflammasome Priming Prevention | 0.584 | neurodegeneration | What are the mechanisms by which gut mic |
| Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in N | 0.582 | neurodegeneration | What are the mechanisms by which gut mic |
| Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re | 0.581 | neurodegeneration | What are the mechanisms by which gut mic |
| Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu | 0.580 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neuroscience | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Systemic inflammation as a central player in the initiation and development of A [PMID:40841660] | Bayraktaroglu I, Ortí-Casañ N, Van Dam D | Immunity & ageing : I & A | 2025 | 1 |
| USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent au [PMID:35900990] | ["Di Q", "Zhao X", "Tang H", "Li X", "Xi | Autophagy | 2023 | 1 |
| USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradatio [PMID:34486483] | ["Cai B", "Zhao J", "Zhang Y", "Liu Y", | Autophagy | 2022 | 1 |
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| Interweaving microglial senescence and gut microbiome dynamics in Alzheimer's di [PMID:41747877] | Waghmare A, Rahangdale S, Khare K, Taksa | Molecular and cellular neurosc | 2026 | 0 |
| The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436] | Gopalakrishna PK, Che Mohd Nassir CMN, A | Cellular and molecular neurobi | 2026 | 0 |
| Elevated expression of the NLRP3 inflammasome in post-mortem brain white matter [PMID:41687275] | Otálora-Alcaraz A, Sun MC, Hofman N, Cos | Multiple sclerosis and related | 2026 | 0 |
| NLRP3 Inflammasome and Polycystic Ovary Syndrome (PCOS): A Novel Profile in Adip [PMID:41596350] | Alenezi SA, Alshammari K, Khan R, Amer S | International journal of molec | 2026 | 0 |
| Exploring the Role of Microglial Cells in the Gut-Brain Axis Communication: A Sy [PMID:40662222] | Ortiz-Samur NS, Vijaya AK, Burokas A, Me | Journal of neurochemistry | 2025 | 0 |
| Sepsis and the Liver. [PMID:41439929] | ["Geladari E", "Kalergi A", "Evangelopou | Diseases (Basel, Switzerland) | 2025 | 0 |
| Molecular links between inflammatory bowel disease and Alzheimer's disease throu [PMID:41480321] | Durairajan SSK, Singh AK, Sulaiman SM, P | World journal of gastroenterol | 2025 | 0 |
| Bone marrow vacuolization to curative strategies: Evolving paradigms in VEXAS sy [PMID:40784090] | ["Elbadry M", "Mabed M"] | Current research in translatio | 2025 | 0 |
| Δ9-Tetrahydrocannabinol and cannabidiol selectively suppress toll-like receptor [PMID:40553974] | Sermet S, Finn BM, Crawford RB, Kaminski | The Journal of pharmacology an | 2025 | 0 |
| Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats. [PMID:40332346] | Borim PA, Gatto M, Mota GAF, Meirelles A | International journal of molec | 2025 | 0 |
| The NLRP3-inflammasome inhibitor MCC950 improves cardiac function in a HFpEF mou [PMID:39616735] | ["Li S", "Withaar C", "Rodrigues P", "Zi | Biomedicine & pharmacotherapy | 2024 | 0 |
| Andrographolide Attenuates NLRP3 Inflammasome Activation and Airway Inflammation [PMID:38808326] | Yu Y, Miao TW, Xiao W, Mao B, Du LY, Wan | Drug design, development and t | 2024 | 0 |
| GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis thro [PMID:36289519] | ["Liu M", "Li H", "Yang R", "Ji D", "Xia | Journal of neuroinflammation | 2022 | 0 |
| T cell-oriented strategies for controlling the COVID-19 pandemic. [PMID:34497383] | ["Noh J", "Jeong H", "Kim J", "Shin E"] | Nature reviews. Immunology | 2021 | 0 |
| Norethisterone and its acetate - what's so special about them? [PMID:32398290] | Huvinen E, Holopainen E, Heikinheimo O | BMJ sexual & reproductive heal | 2021 | 0 |
| Potential application value of PET/computed tomography in retroperitoneal leiomy [PMID:33741860] | ["Gao Y", "Yang Z", "Yu J", "Li N", "Wan | Nuclear medicine communication | 2021 | 0 |