Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Mapk: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Mapk is a biological pathway involved in neurodegeneration research. Key relationships include: activates, therapeutic target, interacts with. Associated with ALS, Aging, Als. Connected to 1724 entities in the SciDEX knowledge graph.
| Name | Mapk |
| Summary | Page for MAPK Signaling Inhibitors: Investment Landscape Analysis |
| Key Genes/Proteins | MTOR, TNF, PI3K, AKT, P38, ERK |
| Related Diseases | Als, Carcinoma, Cancer, Tumor |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
CAT["CAT"] -->|"interacts"| Mapk["Mapk"]
OPTN["OPTN"] -->|"interacts"| Mapk["Mapk"]
DNM1L["DNM1L"] -->|"interacts"| Mapk["Mapk"]
CANX["CANX"] -->|"interacts"| Mapk["Mapk"]
style Mapk fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Senescent Myeloid Cells | causes | cell_type | 0.90 |
| Mitochondrial Fragmentation | causes | process | 0.90 |
| Tumor Growth | associated_with | phenotype | 0.90 |
| Pyroptosis | activates | process | 0.85 |
| Inflammation | activates | process | 0.85 |
| Inflammatory Cytokine Secretion | activates | process | 0.85 |
| Inflammatory Cytokine Expression | regulates | process | 0.85 |
| Lithium Neurotoxicity | involved_in | process | 0.85 |
| Neuroinflammation | involved_in | process | 0.80 |
| Mtor | interacts_with | pathway | 0.55 |
| Toll-Like Receptor | interacts_with | pathway | 0.55 |
| Tgf-Β | interacts_with | pathway | 0.55 |
| Immune Response | interacts_with | pathway | 0.55 |
| Innate Immunity | interacts_with | pathway | 0.55 |
| Mitophagy | interacts_with | pathway | 0.55 |
| Phagocytosis | interacts_with | pathway | 0.55 |
| Nf-Κb | interacts_with | pathway | 0.55 |
| Inflammasome | interacts_with | pathway | 0.55 |
| Endothelial | interacts_with | cell_type | 0.50 |
| Stem Cell | interacts_with | cell_type | 0.50 |
| Dendritic Cell | interacts_with | cell_type | 0.50 |
| Epithelial | interacts_with | cell_type | 0.50 |
| Neuron | encodes | cell_type | 0.50 |
| Interneuron | encodes | cell_type | 0.50 |
| T Cell | activates | cell_type | 0.50 |
| Hepatocyte | activates | cell_type | 0.50 |
| Neutrophil | therapeutic_target | cell_type | 0.50 |
| Microglia | activates | cell_type | 0.50 |
| Fibroblast | therapeutic_target | cell_type | 0.50 |
| Osteoclast | expressed_in | cell_type | 0.50 |
| Neuron | inhibits | cell_type | 0.50 |
| Microglia | contributes_to | cell_type | 0.50 |
| Astrocyte | contributes_to | cell_type | 0.50 |
| Neuron | causes | cell_type | 0.50 |
| B Cell | activates | cell_type | 0.50 |
| Macrophage | activates | cell_type | 0.50 |
| Neuron | contributes_to | cell_type | 0.50 |
| Neuron | activates | cell_type | 0.50 |
| Neuron | associated_with | cell_type | 0.50 |
| Dopaminergic | associated_with | cell_type | 0.50 |
| Macrophage | contributes_to | cell_type | 0.50 |
| Fibroblast | contributes_to | cell_type | 0.50 |
| Pericyte | contributes_to | cell_type | 0.50 |
| Endothelial | contributes_to | cell_type | 0.50 |
| Microglia | inhibits | cell_type | 0.50 |
| Epithelial | activates | cell_type | 0.50 |
| Neuron | therapeutic_target | cell_type | 0.50 |
| Fibroblast | activates | cell_type | 0.50 |
| Endothelial | activates | cell_type | 0.50 |
| Endothelial | therapeutic_target | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MTOR | associated_with | gene | 1.00 |
| TNF | inhibits | gene | 1.00 |
| TNF | therapeutic_target | gene | 1.00 |
| PI3K | associated_with | gene | 1.00 |
| AKT | associated_with | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| P38 | activates | gene | 1.00 |
| ERK | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| ERK | regulates | gene | 1.00 |
| PI3K | regulates | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| AKT | regulates | gene | 1.00 |
| Als | regulates | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| PI3K | activates | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| MTOR | regulates | gene | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Als | activates | disease | 1.00 |
| P38 | therapeutic_target | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| TNF | activates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| EGFR | therapeutic_target | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| PI3K | inhibits | gene | 1.00 |
| MTOR | inhibits | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| P38 | inhibits | gene | 1.00 |
| ERK | inhibits | gene | 1.00 |
| ERK | therapeutic_target | gene | 1.00 |
| AKT | inhibits | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| ERK1 | activates | gene | 1.00 |
| AKT | contributes_to | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxici | 0.609 | neurodegeneration | Should microtubule-stabilizing drugs be |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||