gene

SPPL2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPPL2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

9Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for SPPL2A Gene

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🧬 Gene Info

Gene Symbol	SPPL2A
Chromosome	15q21.3
Protein Type	Protease
Function	encodes an intramembrane aspartyl protease that catalyzes the proteolytic cleavage of type II membrane proteins within their transmembrane domains.
Primary Expression	dopaminergic neurons of the substantia nigra, the brain region most affect
Molecular Weight	69 kDa
Amino Acids	617 aa
Pathways	Notch
UniProt ID	Q8TDS0
NCBI Gene ID	84888
Ensembl ID	ENSG00000119774
GeneCards	SPPL2A
Human Protein Atlas	SPPL2A
Active site residues	Conserved Asp-Thr-Ser-Leu (DTSL) motif in transmembrane domain VI
Y/D motif	Conserved tyrosine-aspartate pair in transmembrane domain VII
Associated Diseases	neurodegeneration
Interactions	AP4E1
KG Connections	10 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SPPL2A — AlphaFold Q8TDS0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    N0["SPPL2A"]
    N1["Alzheimer"]
    N0 -->|"regulates"| N1
    N2["Als"]
    N0 -->|"regulates"| N2
    N3["Tumor"]
    N0 -->|"regulates"| N3
    N4["ALZHEIMER"]
    N0 -->|"regulates"| N4
    N5["AND"]
    N0 -->|"associated with"| N5
    N6["NOTCH"]
    N0 -->|"regulates"| N6
    N7["ALZHEIMER'S DISEASE"]
    N0 -->|"regulates"| N7
    N8["VEGF"]
    N0 -->|"regulates"| N8
    N9["Notch"]
    N0 -->|"regulates"| N9
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 pathway

Outgoing (9)

Target	Relation	Type	Str
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
VEGF	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
AND	associated_with	gene	0.60
NOTCH	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
Notch	regulates	pathway	0.60

Incoming (1)

Source	Relation	Type	Str
AP4E1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity