pathway

Notch

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Notch: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1603Connections

0Hypotheses

0Analyses

39Outgoing

50Incoming

Summary

Notch is a biological pathway involved in neurodegeneration research. Key relationships include: therapeutic target, activates, regulates. Associated with Aging, Als, Alzheimer. Connected to 537 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Notch
Summary	Companies developing Notch signaling modulators and gamma-secretase inhibitors/modulators for Alzheimer's disease therapy
Key Genes/Proteins	CANCER, NOTCH1, GENES, INFLAMMATION
Related Diseases	Cancer, Als, Tumor, Inflammation

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Notch["Notch"] -->|"interacts"| Wnt["Wnt"]
    Notch["Notch"] -->|"interacts"| Tgf__["Tgf-Beta"]
    Notch["Notch"] -->|"interacts"| Epigenetic["Epigenetic"]
    Notch["Notch"] -->|"interacts"| Mtor["Mtor"]
    Notch["Notch"] -->|"interacts"| Adaptive_Immunity["Adaptive Immunity"]
    Notch["Notch"] -->|"interacts"| Apoptosis["Apoptosis"]
    GAIN["GAIN"] -.->|"inhibits"| Notch["Notch"]
    PP2A["PP2A"] -->|"associated"| Notch["Notch"]
    STAR["STAR"] -->|"associated"| Notch["Notch"]
    ORAI1["ORAI1"] -->|"regulates"| Notch["Notch"]
    style Notch fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (459)

Target	Relation	Type	Str
Wnt	interacts_with	pathway	0.55
Tgf-Β	interacts_with	pathway	0.55
Epigenetic	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Adaptive Immunity	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Endothelial	regulates	cell_type	0.50
Macrophage	inhibits	cell_type	0.50
Epithelial	contributes_to	cell_type	0.50
Neural Progenitor	regulates	cell_type	0.50
Stem Cell	regulates	cell_type	0.50
Neuron	activates	cell_type	0.50
Astrocyte	inhibits	cell_type	0.50
Epithelial	therapeutic_target	cell_type	0.50
T Cell	activates	cell_type	0.50
Neuron	therapeutic_target	cell_type	0.50
Epithelial	activates	cell_type	0.50
Cardiomyocyte	therapeutic_target	cell_type	0.50
Astrocyte	activates	cell_type	0.50
T Cell	interacts_with	cell_type	0.50
Neuron	interacts_with	cell_type	0.50
Radial Glia	regulates	cell_type	0.50
Neuron	regulates	cell_type	0.50
Neuron	expressed_in	cell_type	0.50
Endothelial	activates	cell_type	0.50
Astrocyte	regulates	cell_type	0.50
Fibroblast	regulates	cell_type	0.50
Fibroblast	inhibits	cell_type	0.50
Epithelial	associated_with	cell_type	0.50
Osteoblast	expressed_in	cell_type	0.50
T Cell	expressed_in	cell_type	0.50
Osteoclast	expressed_in	cell_type	0.50
Stem Cell	therapeutic_target	cell_type	0.50
Osteoblast	activates	cell_type	0.50
Stem Cell	activates	cell_type	0.50
Stem Cell	contributes_to	cell_type	0.50
T Cell	regulates	cell_type	0.50
Neuron	associated_with	cell_type	0.50
Astrocyte	associated_with	cell_type	0.50

Incoming (1144)

Source	Relation	Type	Str
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
CANCER	therapeutic_target	gene	1.00
Tumor	therapeutic_target	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Als	regulates	disease	1.00
Inflammation	activates	disease	1.00
NOTCH1	inhibits	gene	0.90
GENES	regulates	gene	0.90
Cancer	regulates	disease	0.90
Als	activates	disease	0.90
GENES	associated_with	gene	0.90
Inflammation	regulates	disease	0.90
GENES	therapeutic_target	gene	0.90
INFLAMMATION	therapeutic_target	gene	0.90
CANCER	regulates	gene	0.90
INFLAMMATION	activates	gene	0.90
CANCER	associated_with	gene	0.90
Tumor	inhibits	disease	0.80
NOTCH1	expressed_in	gene	0.80
Als	expressed_in	disease	0.80
Als	associated_with	disease	0.80
PI3K	associated_with	gene	0.80
AKT	associated_with	gene	0.80
PI3K	regulates	gene	0.80
APOPTOSIS	regulates	gene	0.80
ALZHEIMER'S DISEASE	regulates	gene	0.80
NF-ΚB	associated_with	gene	0.80
MIRNAS	regulates	gene	0.80
Leukemia	therapeutic_target	disease	0.80
ROS	activates	gene	0.80
Cancer	associated_with	disease	0.80
Aging	activates	disease	0.80
Cancer	activates	disease	0.70
DNA	regulates	gene	0.70
Neurodegeneration	activates	disease	0.70
Aging	contributes_to	disease	0.70
Carcinoma	regulates	disease	0.70
HES1	expressed_in	gene	0.70
Ischemia	activates	disease	0.70
Neuroinflammation	regulates	disease	0.70
Autoimmune	regulates	disease	0.70
ABCB1	therapeutic_target	gene	0.70
CD44	therapeutic_target	gene	0.70
Fibrosis	therapeutic_target	disease	0.70
Carcinoma	therapeutic_target	disease	0.70
NF-ΚB	interacts_with	gene	0.70
AKT	expressed_in	gene	0.70
IL-6	activates	gene	0.70
NEUROINFLAMMATION	activates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Notch

Understanding Entity Pages

Summary

Wiki Pages (21)

Notch Signaling and Gamma-Secretase Modulators for Alzheimer's Disease

HNRNPA2B1 Protein

Oligodendrocytes

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

Niemann-Pick Disease Type C (NPC)

Amyloid Cascade Pathway

PEN2 Gene

IGF-1 Signaling Pathway in Neurodegeneration

Astrocytes

Cellular Reprogramming Therapies for Neurodegeneration

Notch Signaling Pathway in Neurodegeneration

FGF10 — Fibroblast Growth Factor 10

Neurogenesis

DLK2 — Delta-Like Non-Canonical Notch Ligand 2

genetics

Meningeal Lymphatics

KRIT1 — Krev Interaction Trapped 1 (CCM1)

Neurogenesis and Neurodegeneration

PSEN2 — Presenilin 2