Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | STK4 |
| Full Name | Serine/Threonine Kinase 4 |
| Aliases | MST1 kinase in Hippo signaling pathway |
| Chromosome | 20q13.12 |
| Protein Family | STE20 family, Hippo pathway |
| Protein Type | Serine/Threonine Kinase |
| Function | is a critical component of the Hippo signaling pathway. |
| Amino Acids | 491 aa |
| UniProt ID | Q13043 |
| NCBI Gene ID | 6789 |
| Ensembl ID | ENSG00000101109 |
| OMIM | 604472 |
| GeneCards | STK4 |
| Human Protein Atlas | STK4 |
| N-terminal kinase domain | Catalytic serine/threonine kinase activity (~300 amino acids) |
| Associated Diseases | neurodegeneration |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
STK4["<b>STK4</b>"]
Anxiety{"Anxiety"}
STK4 -->|"activates"| Anxiety
Ms{"Ms"}
STK4 -->|"regulates"| Ms
Depression{"Depression"}
STK4 -->|"activates"| Depression
neurodegeneration["neurodegeneration"]
STK4 -->|"implicated in"| neurodegeneration
DNAJB12["DNAJB12"]
DNAJB12 -->|"regulates"| STK4
RB1CC1["RB1CC1"]
RB1CC1 -->|"regulates"| STK4
SCN4B["SCN4B"]
SCN4B -->|"regulates"| STK4
style STK4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Anxiety | activates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Depression | activates | disease | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity