gene 1,646 words KG: STK4 2026-03-27
kind:genesection:genesstate:published
Contents

STK4 — Serine/Threonine Kinase 4

🧬 Gene Info
Gene SymbolSTK4
Full NameSerine/Threonine Kinase 4
AliasesMST1 kinase in Hippo signaling pathway
Chromosome20q13.12
Protein FamilySTE20 family, Hippo pathway
Protein TypeSerine/Threonine Kinase
Functionis a critical component of the Hippo signaling pathway.
Amino Acids491 aa
UniProt IDQ13043
NCBI Gene ID6789
Ensembl IDENSG00000101109
OMIM604472
GeneCardsSTK4
Human Protein AtlasSTK4
N-terminal kinase domainCatalytic serine/threonine kinase activity (~300 amino acids)
Associated Diseasesneurodegeneration
KG Connections6 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (4)

SCN4B Gene - Sodium Voltage-Gated Channel Beta Subunit
gene · KG edge: regulates
RB1CC1 Gene
gene · KG edge: regulates
DNAJB12 — DnaJ Heat Shock Protein Family (Hsp40) Member
gene · KG edge: regulates
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (6 edges)

STK4 activates Anxiety
STK4 regulates Ms
STK4 activates Depression
DNAJB12 regulates STK4
RB1CC1 regulates STK4
SCN4B regulates STK4