Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SUFU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SUFU |
| Full Name | Suppressor of Fused, Hedgehog Pathway Regulator |
| Chromosome | 10q24.32 |
| Function | encodes a 484 amino acid cytoplasmic protein that is the principal negative regulator of the Hedgehog (Hh) signaling pathway in vertebrates. |
| Amino Acids | 484 aa |
| Exons | 12 |
| Ensembl ID | ENSG00000107882 |
| GeneCards | SUFU |
| Human Protein Atlas | SUFU |
| Phosphorylation | PKA phosphorylates SUFU at Ser342/Ser346, stabilizing the protein and enhancing its GLI-binding capacity |
| Ubiquitination | The SPOP–Cullin3 E3 ligase complex ubiquitinates SUFU for proteasomal degradation upon sustained Hedgehog pathway activation, providing a negative feedback loop |
| SUMOylation | SUMO modification of SUFU enhances nuclear retention and repressor function of GLI |
| Dual phosphatase regulation | PP2A and PP4 dephosphorylate SUFU to reduce its stability, allowing graded pathway activation |
| Cortical development | SUFU regulates the balance between neural progenitor expansion and differentiation. Its conditional deletion in cortical progenitors causes over-proliferation and cortical dysplasia |
| Oligodendrocyte differentiation | SUFU modulates the timing of oligodendrocyte precursor cell (OPC) differentiation by controlling GLI-dependent transcription of proliferation and differentiation genes |
| Associated Diseases | neurodegeneration |
| Interactions | SMARCB1, NF2, LZTR1, GENES |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
SUFU(["SUFU"])
Tumor["Tumor"]
Als["Als"]
DNA(["DNA"])
SMARCB1(["SMARCB1"])
NF2(["NF2"])
LZTR1(["LZTR1"])
GENES(["GENES"])
neurodegeneration["neurodegeneration"]
SUFU -.->|"inhibits"| Tumor
SUFU -->|"expressed in"| Als
SUFU -->|"expressed in"| DNA
SMARCB1 -.->|"inhibits"| SUFU
NF2 -.->|"inhibits"| SUFU
LZTR1 -.->|"inhibits"| SUFU
GENES -.->|"inhibits"| SUFU
SUFU -->|"implicated in"| neurodegeneration
style SUFU fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fffHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||