NF2

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NF2 tumor suppressor (Merlin/Schwannomin) in neurofibromatosis, CNS tumors and neurodegeneration

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graph TD
    NF2["<b>NF2</b>"]
    neurofibromatosis_type_2{"neurofibromatosis type 2"}
    NF2 -->|"causes"| neurofibromatosis_type_2
    Tumor{"Tumor"}
    NF2 -->|"causes"| Tumor
    PI3K_AKT(["PI3K/AKT"])
    NF2 -->|"regulates"| PI3K_AKT
    RAF_MEK_ERK(["RAF/MEK/ERK"])
    NF2 -->|"regulates"| RAF_MEK_ERK
    MAPK(["MAPK"])
    NF2 -->|"regulates"| MAPK
    merlin["merlin"]
    NF2 -->|"encodes"| merlin
    Cardiovascular["Cardiovascular"]
    NF2 -->|"regulates"| Cardiovascular
    Als{"Als"}
    NF2 -->|"associated with"| Als
    Ms{"Ms"}
    NF2 -->|"inhibits"| Ms
    NF2 -->|"inhibits"| Tumor
    Cancer{"Cancer"}
    NF2 -->|"interacts with"| Cancer
    NF2 -->|"activates"| Cancer
    MTOR["MTOR"]
    MTOR -->|"inhibits"| NF2
    ERK["ERK"]
    ERK -->|"inhibits"| NF2
    PI3K["PI3K"]
    PI3K -->|"inhibits"| NF2
    AKT["AKT"]
    AKT -->|"inhibits"| NF2
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"interacts with"| NF2
    CANCER["CANCER"]
    CANCER -->|"interacts with"| NF2
    YAP["YAP"]
    YAP -->|"interacts with"| NF2
    MEF2C["MEF2C"]
    MEF2C -->|"activates"| NF2
    LAMA2["LAMA2"]
    LAMA2 -->|"regulates"| NF2
    BCL2L13["BCL2L13"]
    BCL2L13 -->|"associated with"| NF2
    style NF2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0