concept

LZTR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LZTR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

133Connections

0Hypotheses

0Analyses

50Outgoing

39Incoming

Summary

LZTR1 is a concept in neurodegeneration research. Key relationships include: inhibits, implicated in, associated with. Associated with AD, ALI, ALS. Connected to 72 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	LZTR1
Key Genes/Proteins	GENES, NF2, SUST, RAS
Related Diseases	Tumor, Als, schwannomatosis, neurofibromatosis, Ms

Wiki Pages (4)

Knowledge base pages for this entity

eef1a1

gene · 2617 words

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SUMF1 - Sulfatase Modifying Factor 1

gene · 2144 words

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SMARCB1 — SWI/SNF Related Matrix Associated Actin Dependent Regulator of Chromatin Subfamily B Member 1

gene · 1352 words

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NF2 — Merlin/Neurofibromin 2

gene · 1201 words

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Pathway Diagram

graph TD
    LZTR1["LZTR1"]
    LZTR1 -->|"causes"| Tumor["Tumor"]
    LZTR1 -->|"inhibits"| Als["Als"]
    LZTR1 -->|"inhibits"| Ms["Ms"]
    LZTR1 -->|"inhibits"| ALS["ALS"]
    LZTR1 -->|"inhibits"| Carcinoma["Carcinoma"]
    LZTR1 -->|"inhibits"| Cancer["Cancer"]
    LZTR1 -->|"inhibits"| SMARCB1["SMARCB1"]
    LZTR1 -->|"inhibits"| NF1["NF1"]
    LZTR1 -->|"inhibits"| Mapk["Mapk"]
    MTOR["MTOR"] -->|"inhibits"| LZTR1
    ERK["ERK"] -->|"inhibits"| LZTR1
    PI3K["PI3K"] -->|"inhibits"| LZTR1
    AKT["AKT"] -->|"inhibits"| LZTR1
    NF2["NF2"] -->|"inhibits"| LZTR1
    MDM4["MDM4"] -->|"inhibits"| LZTR1
    JUN["JUN"] -->|"inhibits"| LZTR1
    MET["MET"] -->|"inhibits"| LZTR1
    MCL1["MCL1"] -->|"inhibits"| LZTR1
    VEGFA["VEGFA"] -->|"inhibits"| LZTR1

Outgoing (94)

Target	Relation	Type	Str
Tumor	inhibits	disease	0.85
Als	inhibits	disease	0.75
schwannomatosis	associated_with	disease	0.70
neurofibromatosis	associated_with	disease	0.70
Tumor	causes	disease	0.70
GENES	inhibits	gene	0.70
Ms	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
RAS	inhibits	gene	0.65
UBIQUITIN	inhibits	gene	0.65
Cancer	therapeutic_target	disease	0.65
SMARCB1	inhibits	gene	0.60
NF1	inhibits	gene	0.60
Mapk	inhibits	pathway	0.60
Akt	inhibits	pathway	0.60
Mtor	inhibits	pathway	0.60
Pi3K	inhibits	pathway	0.60
Dna Methylation	inhibits	pathway	0.60
Wnt	inhibits	pathway	0.60
SMARCB1	associated_with	gene	0.60
GENES	implicated_in	gene	0.60
NF2	contributes_to	gene	0.60
SUFU	inhibits	gene	0.60
DNA	expressed_in	gene	0.60
GENES	causes	gene	0.60
AKT	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
Pi3K/Akt	inhibits	pathway	0.60
GENES	associated_with	gene	0.60
AND	inhibits	gene	0.60
SF3B1	associated_with	gene	0.60
APOB	inhibits	gene	0.60
EEF1A1	associated_with	gene	0.60
P53	inhibits	gene	0.60
RNA	inhibits	gene	0.60
MDM4	inhibits	gene	0.60
SMARCA4	associated_with	gene	0.60
TERT	inhibits	gene	0.60
JUN	inhibits	gene	0.60
AND	associated_with	gene	0.60
CANCER	inhibits	gene	0.60
IDH1	inhibits	gene	0.60
DNA	associated_with	gene	0.60
PD-1	inhibits	gene	0.60
VEGFA	inhibits	gene	0.60
MCL1	inhibits	gene	0.60

Incoming (39)

Source	Relation	Type	Str
NF2	inhibits	gene	0.70
SUST	associated_with	gene	0.70
SMARCB1	inhibits	gene	0.70
MTOR	inhibits	gene	0.60
ERK	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
AKT	inhibits	gene	0.60
EEF1A1	associated_with	gene	0.60
MDM4	inhibits	gene	0.60
JUN	inhibits	gene	0.60
MET	inhibits	gene	0.60
DNA	associated_with	gene	0.60
MCL1	inhibits	gene	0.60
VEGFA	inhibits	gene	0.60
SMARCA4	associated_with	gene	0.60
SF3B1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
P53	inhibits	gene	0.60
APOB	inhibits	gene	0.60
TERT	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
IDH1	inhibits	gene	0.60
SMARCB1	causes	gene	0.60
GAIN	therapeutic_target	gene	0.60
NF2	causes	gene	0.60
NF1	inhibits	gene	0.60
RAS	inhibits	gene	0.60
AND	contributes_to	gene	0.60
MAPK	inhibits	gene	0.60
PD-L1	inhibits	gene	0.60
WNT	inhibits	gene	0.60
AND	inhibits	gene	0.60
MCL1	therapeutic_target	gene	0.60
MDM4	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
WNT	therapeutic_target	gene	0.60
MAPK	degrades	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found