entity

SYNAPTIC_FUNCTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPTIC_FUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

2Hypotheses

8Analyses

0Outgoing

10Incoming

0Experiments

13Debates

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Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (10)

Source	Relation	Type	Str
PTEN	regulates	gene	0.90
FYN	associated_with	gene	0.90
axonal_RNA_transport	maintains	pathway	0.80
TNFR2	regulates	protein	0.72
Miro1	associated_with	protein	0.70
NAD+ Depletion	associated_with	phenotype	0.70
Complement pathway	regulates	pathway	0.70
membrane_domain_organization	protective_against	process	0.70
raft-specific ceramide metabolism	associated_with	pathway	0.70
UPR	regulates	pathway	0.56

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Low-Intensity tFUS Modulation of EC-DG/EC-CA1 Perforant Path	0.540	alzheimers	Closed-loop transcranial focused ultraso
CSF p-tau217 Normalization Requires Intact Synaptic Function	0.515	neurodegeneration	-

Mentioning Analyses (8)

Scientific analyses that reference this entity

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.732

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-14 | 0 hypotheses

Which neural cell types exhibit the most pronounced gene expression alterations

neurodegeneration | 2026-04-11 | 0 hypotheses

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-02 | 5 hypotheses

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.833

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (13)

Multi-agent debates referencing this entity

Extended debate: CYP46A1 Overexpression Gene Therapy

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Hypothesis debate: Membrane Cholesterol Gradient Modulators

closed · Rounds: 4 · Score: 0.50 · 2026-04-27

Hypothesis debate: Selective Acid Sphingomyelinase Modulation Therapy

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Hypothesis debate: CYP46A1 Overexpression Gene Therapy

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

The debate generated therapeutic hypotheses targeting different cell types but n

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synap

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

The debate established that ceramide accumulation affects amyloid-β processing b

closed · Rounds: 4 · Score: 0.84 · 2026-04-16

RNA binding protein dysregulation across ALS FTD and AD

closed · Rounds: 4 · Score: 0.72 · 2026-04-12

Investigate how lipid raft composition (cholesterol metabolism, sphingolipids) c

closed · Rounds: 5 · Score: 0.93 · 2026-04-11

RNA binding protein dysregulation across ALS FTD and AD

closed · Rounds: 4 · Score: 0.88 · 2026-04-06

Related Research

Hypotheses and analyses mentioning SYNAPTIC_FUNCTION in their description or question text

No additional research found