Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UPR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| PROTEIN_FOLDING | activates | phenotype | 0.72 |
| SYNAPTIC_FUNCTION | regulates | phenotype | 0.56 |
| APOPTOSIS | activates | phenotype | 0.56 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Cell-Type Specific TREM2 Upregulation in DAM Microglia | 0.519 | Alzheimer's Disease | SEA-AD Gene Expression Profiling — Allen |
| Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat | 0.505 | neurodegeneration | Perivascular spaces and glymphatic clear |
| Age-Dependent Complement C4b Upregulation Drives Synaptic Vu | 0.470 | neurodegeneration | Gene expression changes in aging mouse b |
| Astrocytic Connexin-43 Upregulation Enhances Neuroprotective | 0.450 | neurodegeneration | Mitochondrial transfer between neurons a |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-06 | 0 hypotheses
neurodegeneration | 2026-04-06 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and dow [PMID:38677244] | Fei Y, Huang X, Ning F, Qian T, Cui J, W | Biomed Pharmacother | 2024 | 1 |
| NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. [PMID:37683629] | Zhan R, Meng X, Tian D, Xu J, Cui H, Yan | Neuron | 2023 | 1 |
| Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration. [PMID:34199470] | Boal AM, Risner ML, Cooper ML, Wareham L | Cells | 2021 | 1 |
| Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induce [PMID:34217286] | Wang XY, Li XY, Wu CH, Hao Y, Fu PH, Mei | Respir Res | 2021 | 1 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| The glycocalyx: a novel diagnostic and therapeutic target in sepsis. [PMID:30654825] | Uchimido R, Schmidt EP, Shapiro NI | Crit Care | 2019 | 1 |
| Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline [PMID:41618855] | ["Ying H", "Fan H", "Wang Y", "Jiang R", | Advanced science (Weinheim, Ba | 2026 | 0 |
| Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating [PMID:41789580] | Wen Y, Yuan Y, Zhang H, Liu Y | Molecular medicine reports | 2026 | 0 |
| Astrocytes Protect Brain Metastatic Breast Cancer Cells From Chemotherapy Throug [PMID:41486609] | Yakati V, Rao SS | Biotechnol Bioeng | 2026 | 0 |
| The AP-1 transcription factors differentially regulate Cx43 expression in a ERK1 [PMID:41930557] | Basque A, Izichkis LS, Mellet C, Martin | Reprod Biol | 2026 | 0 |
| Hypoxia Modulates Nanovesicle Phenotype and Angiogenic Function From Human Pluri [PMID:41937255] | Lozano J, Rai A, Phang RJ, Cross J, Lim | Proteomics | 2026 | 0 |
| Bladder under stress: Pathological and adaptive shifts in channel expression. [PMID:41945411] | Swärd K, Andersson KE, Uvelius B | Channels (Austin) | 2026 | 0 |
| Danggui Sini decoction attenuates intervertebral disc degeneration by regulating [PMID:41812505] | Chen S, Zhou X, Wang W, Zheng Y, Kang R, | International immunopharmacolo | 2026 | 0 |
| A Single-Cell Transcriptomic Atlas Elucidates a Microglial Gene Signature Linkin [PMID:41884157] | ["Zhong R", "Yang H", "Li X", "Wang F", | Journal of inflammation resear | 2026 | 0 |
| Increased Expression of Connexin 43 Promotes Wnt/β-Catenin Signaling and the Pro [PMID:41757775] | Cai S, Yang X, Chen Z, Chen S, Chen L, C | FASEB journal : official publi | 2026 | 0 |
| Hypoxia Increases Connexin46 and Connexin43 Levels in KNS-42 Glioblastoma Cells. [PMID:41898710] | Minogue PJ, Beyer EC, Berthoud VM | International journal of molec | 2026 | 0 |
| Cx43 modulates malignant phenotypes in bladder cancer cells via the c-Src/PTEN/F [PMID:41910821] | ["Chi Q", "Xu H", "Li H", "Ma G", "Li X" | Journal of molecular histology | 2026 | 0 |
| SnRNA-seq reveals the ameliorative effects of optimized Xueyu Jingshen formula o [PMID:41720010] | Bai J, Xie N, Hou Y, Yan J, Chen M, Yu S | Phytomedicine : international | 2026 | 0 |
| Repurposing of doxycycline as a novel therapeutic avenue for management of parki [PMID:41925933] | Ali NH, Al-Kuraishy HM, Hussain NR, Al-G | Inflammopharmacology | 2026 | 0 |
| Histological findings in follow-up liver biopsies up to 15 years after pediatric [PMID:41370831] | Quintero-Bernabeu J, Salcedo-Allende MT, | Liver Transpl | 2026 | 0 |