UPR

Debate: Microglial TREM2 downregulation impairs damage-associated response in la

closed · Rounds: 4 · Score: 0.21 · 2026-04-27

SEA-AD Single-Cell Analysis: Cell-Type Vulnerability in Alzheimer's Disease

closed · Rounds: 4 · Score: 0.88 · 2026-04-04

TNF-α/NF-κB Axis Upregulates P2RY12 in VSMCs

Score: 0.650 · neurodegeneration · 2026-04-21

## Mechanistic Overview TNF-α/NF-κB Axis Upregulates P2RY12 in VSMCs starts from the claim that modulating RELA (p65), I

Endothelial miR-181c-5p Upregulation Drives Claudin-5 Repression and Paracellula

Score: 0.645 · unknown disease · 2026-04-26

Circulating miR-181c-5p is upregulated in AD patients and directly targets the CLDN5 3'-UTR, suppressing claudin-5 expre

Neuronal TET1 Upregulation Reactivates Immediate-Early Genes and Restores Dendri

Score: 0.640 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The hypothesis centers on the ten-eleven translocation 1 (TET1) enzyme's critical

Optogenetic PV Cell Activation Restores Gamma Power via PV Protein Upregulation

Score: 0.635 · alzheimers · 2026-04-28

Closed-loop stimulation of PV+ interneurons at gamma frequencies (40 Hz) using ChrimsonR rescues gamma oscillation power

C1Q-Induced Foam Cell Formation via Scavenger Receptor Upregulation

Score: 0.620 · neuroinflammation · 2026-04-21

## Mechanistic Overview C1Q-Induced Foam Cell Formation via Scavenger Receptor Upregulation starts from the claim that m

PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-Induced SPP1 Upregulat

Score: 0.618 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The proposed PDGF-BB/PDGFRβ/STAT3 signaling axis represents a complex intercellul

Age-Accelerated miR-155 Upregulation Primes Nigral Microglia for Parkinson's Dis

Score: 0.610 · neuroinflammation · 2026-04-22

## Mechanistic Overview Age-Accelerated miR-155 Upregulation Primes Nigral Microglia for Parkinson's Disease Pathology s

Sigma-1 Receptor-Mediated UPR Reset as Primary Disease-Modifying Mechanism of Tr

Score: 0.605 · unknown disease · 2026-04-26

Trazodone acts as a sigma-1 receptor agonist at doses of 50-100 mg/day, promoting chaperone protein expression in the en

EP4 Receptor Agonism for SLC7A11 Upregulation

Score: 0.550 · neurodegeneration · 2026-04-25

PGE₂ signaling through EP4 receptor transcriptionally upregulates SLC7A11, enhancing cystine uptake and GSH synthesis to

TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Through

Score: 0.496 · neurodegeneration · 2026-04-22

## Mechanistic Overview TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Through CSF1R-Mediated

Platelet-Derived PDGF-BB Primes VSMCs for P2RY12 Upregulation

Score: 0.480 · neurodegeneration · 2026-04-21

## Mechanistic Overview Platelet-Derived PDGF-BB Primes VSMCs for P2RY12 Upregulation starts from the claim that modulat

HBOT at 1.5 ATA for 90 days restores BBB integrity by upregulating claudin-5 and

Score: 0.460 · neurodegeneration · 2026-04-25

HBOT promotes pericyte survival via PDGF-BB/PDGFR-β signaling and upregulates claudin-5 transcription through HIF-2α to

Restoration of Neuronal Ketone Body Utilization via MCT1 Upregulation

Score: 0.459 · metabolomics · 2026-04-25

Restoration of Neuronal Ketone Body Utilization via MCT1 Upregulation

Hippocampal ADCY8 Upregulation for Alzheimer's Navigation Deficits

Score: 0.455 · memory-and-navigation · 2026-04-27

Since spatial navigation deficits are early Alzheimer's symptoms, targeted upregulation of ADCY8 specifically in hippoca

RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivasc

Score: 0.442 · neurodegeneration · 2026-04-22

## Mechanistic Overview RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivascular Fibroblasts